Auto-immune diseases

Question 1

Auto-immunity

Answer 1

Presence of immune responses against self tissues.
Immune system looses its normal regulatory processes and perceives its own tissues as being alien. It forms antibodies against its own tissues (as though it were an external threat)

Question 2

Auto-antibodies

Answer 2

Antibodies produced by the IS against the bodie’s own proteins
Attacks various organs and tissues causing inflammation and damage

Question 3

Epidemiology

M/F, age

Answer 3

More common in women

Younger population

Question 4

High titres of auto-antibodies are MORE/LESS harmful than low titres?

Answer 4

MORE

Question 5

Clinical features

Answer 5

Arthralgia
Myalgia 
Muscle weakness
Fatigue
Alopecia
Mucosal ulcers
Raynaud's phenomenon

Question 6

Examples of auto-immune diseases

Answer 6

SLE 
Anti-Phospholipid syndrome 
Sjorgens syndrome 
Systemic sclerosis 
Polymyositis

Question 7

Anti-CCP antibody

Answer 7

Rheumatoid arthritis

Question 8

Anti- Jo1 antibody

Answer 8

Myositis

Question 9

Anti-DS DNA antibody

Answer 9

SLE

Question 10

Anti-Sm antibody

Answer 10

SLE

Question 11

Anti-Ro antibody

Answer 11

SLE, Sjogrens syndrome

Question 12

Anti-La antibody

Answer 12

Sjogrens syndrome

Question 13

ANA

Answer 13

SLE, Sjogrens syndroms, systemic sclerosis

Question 14

ANCA

Answer 14

Small vessel vasculitis

Question 15

Anti-centromere antibody

Answer 15

Systemic sclerosis (limited)

Question 16

Anti-Scl-70 antibody

Answer 16

Systemic sclerosis (diffuse)

Question 17

Anti-RNP antibody

Answer 17

SLE, mixed CTD

Question 18

SLE auto-antibodies

Answer 18

ANA
Anti-DS antibody
Anti-Sm antibody
Anti-Ro
Anti-RNP

Question 19

Sjogrens auto-antibodies

Answer 19

Anti-Ro

Anti-La