Drug and receptor properties

Question 1

affinity

Answer 1

strength of binding to target, the probability the drug will bind to the target at any given time

Question 2

efficacy

Answer 2

the inherent property and ability of an agonist to cause a cellular response

Question 3

potency

Answer 3

how much of a drug is required to achieve a cellular response

Question 4

steps of response

Answer 4

Binding activation, signal transduction

Question 5

drug dependent parameters

Answer 5

ability to bind to the receptor

intrinsic efficacy

Question 6

down regulation

Answer 6

in a prolonged response to deviations from homeostasis, the body may decrease expressions of certain proteins

Question 7

occupancy

Answer 7

proportion of a drug which is bound to receptors at a given concentration