Drug Allergies Flashcards
1
Q
Serum sickness:
A
Syndrome resulting from soluble circulating immune complexes that form under conditions of antigen excess.
2
Q
Serum sickness presentation:
A
Fever, malaise, lymphadenopathy
3
Q
Jarisch-Herxheimer Reaction is caused by:
A
Sudden release of bacterial components from injured and/or killed bacteria.
4
Q
Jarisch-Herxheimer reaction symptoms:
A
RIgors, fever and hypotension
5
Q
Most common manifestations of SLE (5):
A
- Fever
- Malaise
- Rash
- Arthralgias
- Myalgias
6
Q
Interstitial nephritis manifestations (6):
A
- Fever
- Rash
- Eosinophilia
- Proteinuria
- Hematuria
- Eosinophiluria
7
Q
Interstitial nephritis; Humoral mechanism:
A
Antibody mediated mechanism - antibodies to a drug-basement membrane complex
8
Q
Toxic hepatitis manifestation (4):
A
- Eosinophilia
- Fever
- Rash
- Granulomas on biopsy
9
Q
Vasculitis:
A
Inflammation and necrosis of blood vessels.
10
Q
Vasculitis manifestations:
A
- Palpable purpuric lesions
- Papules, nodules, ulcerations or vsiculobullous lesions
- Usually lower extremities
11
Q
Maculopapular rash (3):
A
- Symmetrical, flat red rash
- Begins on the extremities in ambulatory; the back of bedridden pts
- Palms and soles spared
12
Q
Fixed drug eruptions (3):
A
- Single or multiple edematous, pigmented lesion
- Frequently dark red, violet or brownish-pink
- Reappear in the same location when drug reinitiated
13
Q
Phototoxicity (2):
A
- Immediately after drug treatment after a short exposure to sunlight
- UV light results in drug emitting energy that can damage tissue
