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D&T1 Exam II > Dermatopathology III > Flashcards

Dermatopathology III Flashcards

1
Q

Age range for pemphigus vulgaris:

A

30-50

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2
Q

Pemphigus vulgaris:

A

IgG autoantibodies against desmogleins 1 and 3 in desmosomes in the suprabasal deep epidermis and mucosal epithelium.

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3
Q

Pemphigus vulgaris blisters (2):

A
  • Suprabasal split; acantholytic blisters

- Positive Nikolsky sign

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4
Q

Pemphigus foliaceus:

A

Autoantibodies against Dsg1; superficial, subcorneal blisters

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5
Q

Pemphigus vulgaris direct immunofluorescence pattern:

A

Net-like pattern of intracellular IgG deposits

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6
Q

Bullous pemphigoid age range:

A

Elderly

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7
Q

Bullous pemphigoid presents on (5):

A
  • Inner aspects of thighs
  • Flexor surfaces of forearms
  • Axillae
  • Groin
  • Lower abdomen
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8
Q

Bullous pemphigoid target antigens:

A

BPAg1 and BPAg2 in the hemidesmosome.

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9
Q

Bullous pemphigoid blisters:

A

Subepidermal, noncantholytic blisters

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10
Q

Bullous pemphigoid direct immunofluorescence:

A

Linear deposition of C3 and IgG along dermoepidermal junction

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11
Q

Dermatitis Herpetiformis age range:

A

20-60

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12
Q

Dermatitis Herpetiformis etiology:

A

IgA autoantibodies to transglutaminases bind to TG in gut and cross-react with reticulin in fibrils in skin.

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13
Q

Dermatitis Herpetiformis associated with HLAs (3):

A
  • HLA-B8
  • HLA-DR
  • HLA-DQ
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14
Q

Dermatitis Herpetiformis lesions (4):

A
  • Symmetrically grouped
  • Papules and plaques progressing to vesicles and bullae
  • Buttocks, elbows, knees, scapular areas
  • Very pruritic
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15
Q

Dermatitis Herpetiformis type of blister:

A

Subepidermal blister

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16
Q

Direct immunofluorescence of Dermatitis Herpetiformis :

A

Discontinuous granular deposition of IgA in tips of dermal papillae

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17
Q

Dermatitis Herpetiformis diagnosis (3):

A
  • Skin biopsy
  • Antiendomysial antibodies (specific for TG)
  • Endoscopy: blunting of villi in small bowel
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18
Q

Dermatitis Herpetiformis treatment (2):

A
  • Gluten-fee diet (slow)
  • Dapsone (fast)
    • Check G6PD level
19
Q

Porphyria cutanea tarda age range:

A

30-50

20
Q

Porphyria cutanea tarda etiology:

A

Uroporphyrinogen decarboxylase (UROD) deficiency leads to excessive accumulation of porphyrins

21
Q

Porphyria cutanea tarda cause (3):

A
  • Porphyrins make skin photosensitive
  • Tense subepidermal bulla on normal appearing skin in sun exposed areas
  • May also get hypertrichosis on face
22
Q

Porphyria cutanea tarda diagnosis:

A

Test for increased uroporphyrin in urine

- Will fluoresce orange under woods lamp

23
Q

Acne vulgaris pathogenesis:

A

Obstruction of sebaceous follicles by sebum promotes proliferation of p. acnes.

24
Q

Acne rosacea age range:

A

30-50

25
Q

Acne rosacea:

A

Chronic inflammatory disorder that affects blood vessels and pilosebaceous units

26
Q

Acne rosacea 4 stages:

A
  1. Flushing episodes
  2. Persistent erythema and telangiectasias
  3. Pustules and papules
  4. Rhinophyma
27
Q

Panniculitis:

A

Inflammation of fat lobules or the connective tissue septa separating fat lobules

28
Q

Erythema nodosum age range:

A

20-30

29
Q

Erythema nodosum:

A

Inflammatory reaction of connective tissue septa separating fat lobules

30
Q

Erythema nodosum presents as (4):

A
  • Painful, red, subcutaneous, elevated nodules
  • Nodules indurated and poorly circumscribed
  • Usually located on the anterior aspect of the tibia
  • Bilateral but not symmetric
31
Q

Erythema nodosum histology (3):

A
  • Septal panniculitis (little to know necrosis of lobule)
  • Early: widening of septa from fibrin, edema and neutrophilic infiltrate
  • Chronic: Mononuclear cells and granulomatous inflammation of septum with fibrosis
32
Q

Warts:

A

Benign growths caused by infection of epidermal cells with HPV

33
Q

Plantar wart (3):

A
  • HPV 1
  • Flesh colored papule with hyperkeratotic surface
  • Found on underside of foot
34
Q

Condyloma acuminatum (3):

A
  • Soft fleshy pink papillomas on the genitalia, perineum and anus
  • HPV
  • Most common STD
35
Q

Molluscum contagiosum is caused by:

A

Poxvirus

36
Q

Molluscum contagiosum lesions (3):

A
  • Asymptomatic smooth, dome-shaped papules with central umbilication
  • Flesh-colored and translucent
  • Papules have a cheesy core that can be expressed
37
Q

Scabies is caused by:

A

Infection with Sarcoptes scabiei

38
Q

Xanthelasma:

A

Collection of macrophages containing lipid droplets

39
Q

Mongolian spot:

A

Melanocytes located in the dermis instead of epidermis that may be neural crest cells interrupted in migration

40
Q

Cherry angioma (2):

A
  • Bright red, domed, vascular lesions on trunk

- Benign and increase with age

41
Q

Hemangioma of infancy (3):

A
  • Benign tumor of hyperplastic blood vessels
  • Blanchable bright red to deep purple lesions
  • Regression complete by age 10
42
Q

Xeroderma pigmentosum (2):

A
  • Autosomal recessive
  • Decreased ability to repair DNA following damage by UV light due to defects in excision of abnormal nucleotides or defects in replacement of nucleotides following excision
43
Q

Chediak-Higashi syndrome (2):

A
  • Autosomal recessive
  • Immunodeficiency due to defect in neutrophil phagosome lysosome fusion causing abnormal giant lysosomal inclusions visible on peripheral blood smear
44
Q

Albinism:

A

Melanocytes normal in number and location but production of melanin defective due to complete absence of tyrosinase

D&T1 Exam II (18 decks)

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