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Drug Action 1 > Drug Action Exam 3 > Flashcards

Drug Action Exam 3 Flashcards

0
Q

radial muscle adrenergic receptor and effect

A

alpha-1, contraction causing dilation of pupil

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1
Q

radial muscle cholinergic receptor and action

A

None

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2
Q

mydriasis

A

dilation of pupil

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3
Q

miosis

A

shrinking of pupil

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4
Q

iris sphincter cholinergic receptor and effect

A

M3; contraction causing miosis

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5
Q

iris sphincter adrenergic receptor and effect

A

none

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6
Q

ciliary epithelium cholinergic receptor and effect

A

none

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7
Q

ciliary epithelium adrenergic receptor and effect

A

beta-2 increase aqueous producting increase IOP < alpha-2 decreases aqueous production decrease IOP

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8
Q

trabecular meshwork cholinergic receptor and effect

A

none

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9
Q

trabecular meshwork adrenergic receptor and effect

A

beta-2 increase aqueous outflow decrease IOP

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10
Q

atria and ventricles cholinergic receptor and effect

A

M2>M3, decrease contractility and force

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11
Q

atria and ventricles adrenergic receptor and effect

A

beta-1>beta-2; increase contractility and force

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12
Q

SA and AV nodes cholinergic receptor and effect

A

M2>M3; decrease heart rate

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13
Q

SA and AV nodes adrenergic receptor and effect

A

beta-1>beta-2; increase heart rate

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14
Q

arteries and veins cholinergic receptor and effect

A

M3; vasodilation, decreased BP

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15
Q

arteries and veins adrenergic receptor and effect

A

alpha-1, vasoconstriction increased BP

alpha-2, beta-2, vasodilation decreased BP

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16
Q

skeletal muscle blood vessels cholinergic receptor and effect

A

none

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17
Q

skeletal muscle blood vessels adrenergic receptors and effect

A

beta-2, vasodilation

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18
Q

bronchial smooth muscle cholinergic receptor and effect

A

M3, bronchoconstriction

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19
Q

bronchial smooth muscle adrenergic receptor and effect

A

beta-2, bronchodilation

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20
Q

stomach motility and tone cholinergic receptor and effect

A

M2, M3; increased motility and tone

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21
Q

stomach motility and tone adrenergic receptor and effect

A

alpha-1, alpha-2, beta-1, beta-2; decreased motility and tone

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22
Q

GI sphincters cholinergic receptor and effect

A

M2,M3; relaxation

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23
Q

GI sphincters adrenergic receptor and effect

A

alpha-1; contraction

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24
Q

GI secretions cholinergic receptor and effect

A

M2, M3; increase secretions

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25
Q

GI secretions adrenergic receptor and effect

A

alpha-2; decrease secretion

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26
Q

renin release cholinergic receptor and effect

A

none

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27
Q

renin release adrenergic receptor and effect

A

beta-1, increase renin release

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28
Q

pancreas beta cells cholinergic receptor and effect

A

none

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29
Q

pancreas beta cells adrenergic receptor and effect

A

alpha-2 decrease insulin secretion > beta-2 increase insulin secretion

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30
Q

sweat glands cholinergic receptor and effect

A

none

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31
Q

sweat glands adrenergic receptor and effect

A

alpha-1 (localized), M2, M3; increase sweat

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32
Q

urinary bladder detrussor cholinergic receptor and effect

A

M3>M2; contraction

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33
Q

urinary bladder detrussor adrenergic receptor and effect

A

beta-2, beta-3 (dominant); relaxation

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34
Q

urinary bladder trigone and sphincter cholinergic receptor and effect

A

M3>M2; relaxation

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35
Q

urinary bladder trigone adrenergic receptor and effect

A

alpha-1, contraction

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36
Q

Epi is agonist at

A

alpha-1, alpha-2, beta-1, beta-2, beta-3

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37
Q

Norepi is agonist at

A

alpha-1, beta-1 > beta-2

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38
Q

glaucoma IOP

A

> 26 mmHg

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39
Q

pilocarpine eye

A

muscarinic agonist; open angle glaucoma, reverse mydriasis

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40
Q

benthanecol GI

A

increase GI motility postsurgery

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41
Q

pilocarpine GI

A

muscarinic agonist; xerostomia, Sjorgen’s syndrome; increase salivation/secretions

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42
Q

bethanochol GU

A

stimulates detrussor muscle to contract; for postop urinary retention

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43
Q

pyridostigmine

A

myasthenia gravis, treat nondepolarizing neuromuscular blockers; reversible AChEI

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44
Q

neostigmine

A

myasthenia gravis, reverse nondepolarizing neuromuscular blocking agents, treatment of postop urinary retential and intestinal atony; reversible AChEI

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45
Q

physostigmine

A

glaucoma, myasthenia gravis, treatment of overdose of agents with significant anticholinergic activity; reversible AChEI

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46
Q

donepezil

A

AD; reversible nonclassical AChEI

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47
Q

galantamine

A

AD; reversible nonclassical AChEI

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48
Q

rivastigmine

A

AD; reversible classical AChEI and BuChEI

49
Q

tacrine

A

AD; reversible nonclassical AChEI

50
Q

malathion

A

lice; irreversible AChEI

51
Q

Echothiophate

A

glaucoma; irreversible AChEI

52
Q

diazinon

A

insecticides; irreversible AChEI

53
Q

sarin, soman

A

nerve gas; irreversible AChEI

54
Q

pralidoxime

A

organophosphate antidote

55
Q

atropine cardiac

A

muscarinic antagonist; increase HR to treat AV nodal hert block, sinus bradycardia

56
Q

ipatropium Br

A

COPD, prevent asthma, rhinorrhea; muscarinic antagonist M1 M3

57
Q

tiotropium

A

COPD; muscarinic antagonist

58
Q

aclidinium Br

A

COPD; muscarinic antagonist

59
Q

scopalamine

A

motion sickness; muscarinic antagonist

60
Q

Lomitil

A

muscarinic antagonist; IBS w/diarrhea

61
Q

dicyclomine

A

muscarinic antagonist; IBS/diarrhea

62
Q

tropicamide

A

muscarinic antagonist, cyclopegic mydriatic; ocular diagnostic agent

63
Q

ditropan IR

A

nonselective muscarinic antagonist; urinary incontinence

64
Q

ditropan IR SE

A

D: 71%
C: 15%

65
Q

Ditropan XL

A

muscarinic antagonist; urinary incontinence

66
Q

Ditropan XL SE

A

D: 45%
C: 10%

67
Q

Oxytrol

A

muscarinic antagonist; urinary incontinence

68
Q

Oxytrol SE

A

D: 7%
C: 3%

69
Q

Gelnique

A

muscarinic antagonist; urinary incontinence

70
Q

Gelnique SE

A

D: 7%
C: 1%

71
Q

Detrol

A

nonselective muscarinic antagonist; urinary incontinence

72
Q

Detrol SE

A

D: 35%
C: 7%

73
Q

Detrol LA

A

nonselective muscarinic antagonist; urinary incontinence

74
Q

Detrol LA SE

A

D: 25%
C: 6%

75
Q

Sanctura

A

nonselective muscarinic antagonist; urinary incontinence

76
Q

Sancture SE

A

D: 6:
C: 5%

77
Q

Sanctura SR

A

nonselective muscarinic antagonist; urinary incontinence

78
Q

Sanctura SR SE

A

D: 11%
C: 9%

79
Q

Enablex

A

muscarinic antagonist; urinary incontinence

80
Q

Enablex SE

A

D: 20%
C: 15%

81
Q

Toviaz

A

muscarinic antagonist; urinary incontinence

82
Q

VESIcare

A

muscarinic antagonist; urinary incontinence

83
Q

VESIcare SE

A

D: 20%
C: 9%

84
Q

G protein beta-gamma subunit

A

increase K channels, decrease Ca channels, increase PI3 K

85
Q

M2, M4

A

Gi decrease cAMP

86
Q

M1, M3, M5

A

Gq activate PLC produce DAG IP3

87
Q

ACh eye

A

cholinergic agonist; ocular surgery

88
Q

carbachol

A

cholinergic agonist; glaucoma, miosis during surgery

89
Q

methacholine

A

muscarinic agonist; diagnostic agent for asthma/COPD

90
Q

cevimeline HCl

A

muscarininc agonist; dry mouth d/t Sjorgen’s syndrome

91
Q

varenicline tartrate

A

alpha-4-beta-2 nicotinic partial agonist; smoking cessation

92
Q

Edrophonium Cl

A

nonclassical reversible AChEI; diagnosis of myasthenia gravis, reverse nondepolarizing neuromuscular blocking agents

93
Q

demecarium Br

A

glaucoma; reversible AChEI

94
Q

abenonium Cl

A

myasthenia gravis; reversible AChEI

95
Q

carbaryl

A

insecticide; reversible AChEI

96
Q

isoflurophate

A

glaucoma; irreversible AChEI

97
Q

VX

A

nerve gas; irreversible AChEI

98
Q

Parathion

A

insecticide; irreversible AChEI

99
Q

memantine

A

AD; NMDA antagonist

100
Q

atropine

A

muscarinic antagonist; GI antispasmodic, antidote for poisoning/overdose of muscarinic agents, cholinesterasse inhibitors, organophosphates, ophthalmic

101
Q

hyoscyamine

A

muscarinic antagonist; GI disorders, hypermotility of urinary tract, PUB, IBS, enterocolitis, diverticulitis, abdominal cramps, biliary and renal colic

102
Q

belladonna tincture

A

muscarinic antagonist; antidysmenorrheal, antivertigo, nocturnal enuresis, antisialogogue

103
Q

glycopyrrolate

A

muscarinic antagonist; PUD, decrease gastric acid secretion, prophylaxis of hypersecretory conditions

104
Q

clinidium Br

A

muscarinic antagonist; GI antispasmodic, decrease acid secretion

105
Q

propantheline br

A

muscarinic antagonist; GI antispasmodic, PUD

106
Q

Mepenzolate Br

A

muscarinic antagonist; GI antispasmodic

107
Q

benzotropine mesylate

A

muscarinic antagonist; parkinsonism

108
Q

trihexyphenidyl HCl

A

muscarinic antagonist; parkinsonism

109
Q

diphenhydramine

A

muscarinic antagonist, antihistamine; parkinsonism, antiemetic/antivertigo

110
Q

cyclizine HCl

A

antihistamine; antiemetic/antivertigo

111
Q

meclizine HCl

A

antihistamine; antiemetic/antivertigo

112
Q

cyclopentolate HCl

A

muscarinic antagonist, cyclopegic mydriatic; ocular diagnostic agent

113
Q

homotropine Br

A

muscarinic antagonist, cyclopegic mydriatic

114
Q

atracurium Br

A

nondepolarizing neuromuscular blocking agent

115
Q

cistracurium besylate

A

nondepolarizing neuromuscular blocking agent

116
Q

pancuronium Br

A

nondepolarizing neuromuscular blocking agent

117
Q

vercuronium Br

A

nondepolarizing neuromuscular blocking agent

118
Q

rocuronium Br

A

nondepolarizing neuromuscular blocking agent

119
Q

decamethonium

A

depolarizing neuromuscular blocking agent

120
Q

succinylcholine Cl

A

depolarizing neuromuscular blocking agent

121
Q

sugammadex

A

immediately and rapidly decreases NMBA concentrations

Drug Action 1 (7 decks)

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