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Drug Action 1 > Drug Action Exam 3 > Flashcards

Drug Action Exam 3 Flashcards

0
Q

radial muscle adrenergic receptor and effect

A

alpha-1, contraction causing dilation of pupil

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1
Q

radial muscle cholinergic receptor and action

A

None

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2
Q

mydriasis

A

dilation of pupil

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3
Q

miosis

A

shrinking of pupil

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4
Q

iris sphincter cholinergic receptor and effect

A

M3; contraction causing miosis

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5
Q

iris sphincter adrenergic receptor and effect

A

none

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6
Q

ciliary epithelium cholinergic receptor and effect

A

none

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7
Q

ciliary epithelium adrenergic receptor and effect

A

beta-2 increase aqueous producting increase IOP < alpha-2 decreases aqueous production decrease IOP

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8
Q

trabecular meshwork cholinergic receptor and effect

A

none

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9
Q

trabecular meshwork adrenergic receptor and effect

A

beta-2 increase aqueous outflow decrease IOP

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10
Q

atria and ventricles cholinergic receptor and effect

A

M2>M3, decrease contractility and force

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11
Q

atria and ventricles adrenergic receptor and effect

A

beta-1>beta-2; increase contractility and force

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12
Q

SA and AV nodes cholinergic receptor and effect

A

M2>M3; decrease heart rate

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13
Q

SA and AV nodes adrenergic receptor and effect

A

beta-1>beta-2; increase heart rate

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14
Q

arteries and veins cholinergic receptor and effect

A

M3; vasodilation, decreased BP

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15
Q

arteries and veins adrenergic receptor and effect

A

alpha-1, vasoconstriction increased BP

alpha-2, beta-2, vasodilation decreased BP

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16
Q

skeletal muscle blood vessels cholinergic receptor and effect

A

none

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17
Q

skeletal muscle blood vessels adrenergic receptors and effect

A

beta-2, vasodilation

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18
Q

bronchial smooth muscle cholinergic receptor and effect

A

M3, bronchoconstriction

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19
Q

bronchial smooth muscle adrenergic receptor and effect

A

beta-2, bronchodilation

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20
Q

stomach motility and tone cholinergic receptor and effect

A

M2, M3; increased motility and tone

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21
Q

stomach motility and tone adrenergic receptor and effect

A

alpha-1, alpha-2, beta-1, beta-2; decreased motility and tone

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22
Q

GI sphincters cholinergic receptor and effect

A

M2,M3; relaxation

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23
Q

GI sphincters adrenergic receptor and effect

A

alpha-1; contraction

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24
GI secretions cholinergic receptor and effect
M2, M3; increase secretions
25
GI secretions adrenergic receptor and effect
alpha-2; decrease secretion
26
renin release cholinergic receptor and effect
none
27
renin release adrenergic receptor and effect
beta-1, increase renin release
28
pancreas beta cells cholinergic receptor and effect
none
29
pancreas beta cells adrenergic receptor and effect
alpha-2 decrease insulin secretion > beta-2 increase insulin secretion
30
sweat glands cholinergic receptor and effect
none
31
sweat glands adrenergic receptor and effect
alpha-1 (localized), M2, M3; increase sweat
32
urinary bladder detrussor cholinergic receptor and effect
M3>M2; contraction
33
urinary bladder detrussor adrenergic receptor and effect
beta-2, beta-3 (dominant); relaxation
34
urinary bladder trigone and sphincter cholinergic receptor and effect
M3>M2; relaxation
35
urinary bladder trigone adrenergic receptor and effect
alpha-1, contraction
36
Epi is agonist at
alpha-1, alpha-2, beta-1, beta-2, beta-3
37
Norepi is agonist at
alpha-1, beta-1 > beta-2
38
glaucoma IOP
>26 mmHg
39
pilocarpine eye
muscarinic agonist; open angle glaucoma, reverse mydriasis
40
benthanecol GI
increase GI motility postsurgery
41
pilocarpine GI
muscarinic agonist; xerostomia, Sjorgen's syndrome; increase salivation/secretions
42
bethanochol GU
stimulates detrussor muscle to contract; for postop urinary retention
43
pyridostigmine
myasthenia gravis, treat nondepolarizing neuromuscular blockers; reversible AChEI
44
neostigmine
myasthenia gravis, reverse nondepolarizing neuromuscular blocking agents, treatment of postop urinary retential and intestinal atony; reversible AChEI
45
physostigmine
glaucoma, myasthenia gravis, treatment of overdose of agents with significant anticholinergic activity; reversible AChEI
46
donepezil
AD; reversible nonclassical AChEI
47
galantamine
AD; reversible nonclassical AChEI
48
rivastigmine
AD; reversible classical AChEI and BuChEI
49
tacrine
AD; reversible nonclassical AChEI
50
malathion
lice; irreversible AChEI
51
Echothiophate
glaucoma; irreversible AChEI
52
diazinon
insecticides; irreversible AChEI
53
sarin, soman
nerve gas; irreversible AChEI
54
pralidoxime
organophosphate antidote
55
atropine cardiac
muscarinic antagonist; increase HR to treat AV nodal hert block, sinus bradycardia
56
ipatropium Br
COPD, prevent asthma, rhinorrhea; muscarinic antagonist M1 M3
57
tiotropium
COPD; muscarinic antagonist
58
aclidinium Br
COPD; muscarinic antagonist
59
scopalamine
motion sickness; muscarinic antagonist
60
Lomitil
muscarinic antagonist; IBS w/diarrhea
61
dicyclomine
muscarinic antagonist; IBS/diarrhea
62
tropicamide
muscarinic antagonist, cyclopegic mydriatic; ocular diagnostic agent
63
ditropan IR
nonselective muscarinic antagonist; urinary incontinence
64
ditropan IR SE
D: 71% C: 15%
65
Ditropan XL
muscarinic antagonist; urinary incontinence
66
Ditropan XL SE
D: 45% C: 10%
67
Oxytrol
muscarinic antagonist; urinary incontinence
68
Oxytrol SE
D: 7% C: 3%
69
Gelnique
muscarinic antagonist; urinary incontinence
70
Gelnique SE
D: 7% C: 1%
71
Detrol
nonselective muscarinic antagonist; urinary incontinence
72
Detrol SE
D: 35% C: 7%
73
Detrol LA
nonselective muscarinic antagonist; urinary incontinence
74
Detrol LA SE
D: 25% C: 6%
75
Sanctura
nonselective muscarinic antagonist; urinary incontinence
76
Sancture SE
D: 6: C: 5%
77
Sanctura SR
nonselective muscarinic antagonist; urinary incontinence
78
Sanctura SR SE
D: 11% C: 9%
79
Enablex
muscarinic antagonist; urinary incontinence
80
Enablex SE
D: 20% C: 15%
81
Toviaz
muscarinic antagonist; urinary incontinence
82
VESIcare
muscarinic antagonist; urinary incontinence
83
VESIcare SE
D: 20% C: 9%
84
G protein beta-gamma subunit
increase K channels, decrease Ca channels, increase PI3 K
85
M2, M4
Gi decrease cAMP
86
M1, M3, M5
Gq activate PLC produce DAG IP3
87
ACh eye
cholinergic agonist; ocular surgery
88
carbachol
cholinergic agonist; glaucoma, miosis during surgery
89
methacholine
muscarinic agonist; diagnostic agent for asthma/COPD
90
cevimeline HCl
muscarininc agonist; dry mouth d/t Sjorgen's syndrome
91
varenicline tartrate
alpha-4-beta-2 nicotinic partial agonist; smoking cessation
92
Edrophonium Cl
nonclassical reversible AChEI; diagnosis of myasthenia gravis, reverse nondepolarizing neuromuscular blocking agents
93
demecarium Br
glaucoma; reversible AChEI
94
abenonium Cl
myasthenia gravis; reversible AChEI
95
carbaryl
insecticide; reversible AChEI
96
isoflurophate
glaucoma; irreversible AChEI
97
VX
nerve gas; irreversible AChEI
98
Parathion
insecticide; irreversible AChEI
99
memantine
AD; NMDA antagonist
100
atropine
muscarinic antagonist; GI antispasmodic, antidote for poisoning/overdose of muscarinic agents, cholinesterasse inhibitors, organophosphates, ophthalmic
101
hyoscyamine
muscarinic antagonist; GI disorders, hypermotility of urinary tract, PUB, IBS, enterocolitis, diverticulitis, abdominal cramps, biliary and renal colic
102
belladonna tincture
muscarinic antagonist; antidysmenorrheal, antivertigo, nocturnal enuresis, antisialogogue
103
glycopyrrolate
muscarinic antagonist; PUD, decrease gastric acid secretion, prophylaxis of hypersecretory conditions
104
clinidium Br
muscarinic antagonist; GI antispasmodic, decrease acid secretion
105
propantheline br
muscarinic antagonist; GI antispasmodic, PUD
106
Mepenzolate Br
muscarinic antagonist; GI antispasmodic
107
benzotropine mesylate
muscarinic antagonist; parkinsonism
108
trihexyphenidyl HCl
muscarinic antagonist; parkinsonism
109
diphenhydramine
muscarinic antagonist, antihistamine; parkinsonism, antiemetic/antivertigo
110
cyclizine HCl
antihistamine; antiemetic/antivertigo
111
meclizine HCl
antihistamine; antiemetic/antivertigo
112
cyclopentolate HCl
muscarinic antagonist, cyclopegic mydriatic; ocular diagnostic agent
113
homotropine Br
muscarinic antagonist, cyclopegic mydriatic
114
atracurium Br
nondepolarizing neuromuscular blocking agent
115
cistracurium besylate
nondepolarizing neuromuscular blocking agent
116
pancuronium Br
nondepolarizing neuromuscular blocking agent
117
vercuronium Br
nondepolarizing neuromuscular blocking agent
118
rocuronium Br
nondepolarizing neuromuscular blocking agent
119
decamethonium
depolarizing neuromuscular blocking agent
120
succinylcholine Cl
depolarizing neuromuscular blocking agent
121
sugammadex
immediately and rapidly decreases NMBA concentrations

Drug Action 1 (7 decks)

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