Drug Action Flashcards
1
Q
what are the 4 main modes of drug action?
A
- activating or blocking receptors
- opening or blocking ion channels
- activating or blocking enzyme function
- facilitation or blocking of transport systems
2
Q
is drug/receptor interaction enough?
A
NO!
3
Q
what is meant by affinity?
A
the tightness of the drug binding to the receptor
4
Q
what is meant by occupancy?
A
how much time the drug spends on the receptor
5
Q
what is meant by efficacy?
A
how effective the drug is at producing a response from the receptor
6
Q
what occurs when the drug concentration is higher?
A
more receptors are occupied at any time therefor more response achieved
7
Q
what is an agonist?
A
binds to a receptor and causes an effect
8
Q
how is a partial agonist different?
A
more difficult to produce the drug/receptor effect than with normal agonist
9
Q
how can drugs change enzyme action?
A
- substrate antagonism
* non-competitive substrate inhibition
10
Q
is substrate antagonism competitive or non-competitive?
A
competitive
