Coeliac Disease and Pernicious Anaemia Flashcards
1
Q
what is coeliac disease?
A
sensitivity to alpha-gliaden component of gluten
2
Q
what is gluten found in?
A
- wheat
- barley
- rye
etc.
3
Q
what occurs to the GI tract of a coeliac disease patient?
A
villous atrophy
4
Q
what causes the villous atrophy in coeliac disease patients?
A
T lymphocytes damage mucosal tissue
5
Q
what are classic symptoms of coeliac disease?
A
- weight loss
- weakness
- abdominal pain/swelling
- diarrhoea
- lassitude
6
Q
how can coeliac disease be diagnosed?
A
- antibody tests
- jejunal biopsy
- faecal fat test
- haematinics tests
7
Q
what occurs if a coeliac patient transfers to a gluten free diet?
A
- reversal of jejunal atrophy
- reduced risk of lymphoma
- improved well being
8
Q
what skin disease is coeliac associated with?
A
dermatitis herpetiformis
9
Q
what occurs with Dermatitis Herpetiformis?
A
- itch and blisters on skin (usually over the shoulders but can be widespread)
- oral ulceration and blisters
10
Q
what is pernicious anaemia?
A
disease caused by Vitamin B12 deficiency
11
Q
what are some causes of pernicious anaemia?
A
- lack of Vitamin B12 in the diet
- disease of gastric parietal cells
- inflammatory bowel disease of terminal ileum
- bowel cancer at ileo-coecal junction
