Drug Absorption

Question 1

Physico-chemical factors that affect the transfer of drugs across cell membranes

Answer 1

ionisation, lipid solubility, structure

Question 2

factors that affect the absorption of a drug from the GI tract

Answer 2

motility, food, illness

Question 3

medical importance of first pass metabolism

Answer 3

metabolism of drug prior to it reaching the site of absorption

occurs in: Gut lumen, gut wall, liver

drugs and illness

Question 4

benefits of IV

Answer 4

100% bioavailability

avoids first pass metabolism

Question 5

benefits of topical

Answer 5

can achieve local or systemic effects

able to achieve controlled, sustained doses of the drug

avoids first pass metabolism

Question 6

benefits of inhalation

Answer 6

Drug delivered directly to site of action

rapid effect

small doses used

little systemic absorption

reduced adverse effects