DOTD pt3

Question 1

Drug Class: Semaglutide

Answer 1

Glucagon-like peptide-1 (GLP-1) receptor agonists (Incretin mimetics)

Question 2

Drug Class: Flecainide

Answer 2

Class 1C antiarrhythmic agent - Na channel blocker

Question 3

Drug Class: Aspirin

Answer 3

COX inhibitor

Question 4

Drug Class: Celecoxib

Answer 4

NSAID

Question 5

Drug Class: Azathioprine

Answer 5

Immunosuppressant

Question 6

Indications: Semaglutide

Answer 6

T2DM, Weight loss

Question 7

Indications: Flecainide

Answer 7

Supraventricular arrhythmia, premature ventricular contraction, Wolff-Parkinson-White syndrome

Question 8

Indications: Aspirin

Answer 8

AF post stroke, secondary prevention of stroke, TIA and acute coronary syndromes, during acute coronary syndromes, co prescribed with other antiplatelets

Question 9

Indications: Celecoxib

Answer 9

Oseoarthritis, RA, ankylosing spondylitis

Question 10

Indications: Azathioprine

Answer 10

IBD, vasculitis, SLE

Question 11

Mechanism of action: Semaglutide

Answer 11

Increases Glu dependent synthesis of insulin secretion from beta cells, activate GLP-1 R

Question 12

Mechanism of action: Flecainide

Answer 12

Na channel blocker

Question 13

Mechanism of action: Aspirin

Answer 13

Reduction of TXA2 synthesis via COX-1 inhibition

Question 14

Mechanism of action: Celecoxib

Answer 14

Selective COX-2 inhibitor

Question 15

Mechanism of action: Azathioprine

Answer 15

Anti-metabolite, decreases DNA and RNA synthesis

Question 16

Adverse drug reactions: Semaglutide

Answer 16

GI upset, decreased appetite with weight loss

Question 17

Adverse drug reactions: Flecainide

Answer 17

CNS - drowsiness, dizziness
GI - N&V
Flecainide flutter (increased ventricular response to supravent arrhythmia)
Pro-arrhythmia and sudden death with long term use

Question 18

Adverse drug reactions: Aspirin

Answer 18

GI upset, GI bleeding, haemorrhage (stroke), hypersensitivity

Question 19

Adverse drug reactions: Celecoxib

Answer 19

GI bleed, renal impairment, increased risk of MI

Question 20

Adverse drug reactions: Azathioprine

Answer 20

Bone marrow suppression, infection, hepatitis

Question 21

Contraindications, Warnings, DDIs: Semaglutide

Answer 21

Hypoglycaemic agents
Renal impairment

Question 22

Contraindications, Warnings, DDIs: Flecainide

Answer 22

Other antiarrhythmics
Drugs that also prolong QT interval
Should be prescribed with beta blocker

Question 23

Contraindications, Warnings, DDIs: Aspirin

Answer 23

Reye’s syndrome <16 years old, hypersensitivity, premature closure of ductus arteriosus in 3rd trimester, PPI protection required if long term
Caution when co-prescribed with other antiplatelets or anticoags (additive effects)

Question 24

Contraindications, Warnings, DDIs: Celecoxib

Answer 24

Displace other bound drugs -> increased free drug conc e.g. warfarin, methotrexate

Question 25

Contraindications, Warnings, DDIs: Azathioprine

Answer 25

Measure TPMT before starting