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SRNAClinical Practicuum Prep > DOSES only Induction agents > Flashcards

DOSES only Induction agents Flashcards

1
Q

Propofol IV induction dose is ______

A

1-2 mg/kg

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2
Q

Propofol IV maintenance dose is

A

20-200mcg/kg/min

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3
Q

Ketamine IV induction dose is

A

1 - 2mg/kg

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4
Q

Propofol antiemetic dose

A

10-20mg IV

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5
Q

Ketamine IV maintenance dose

A

1-3 mg/min

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6
Q

Ketamine analgesia dose

A

0.1-0.3 mg/kg

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7
Q

Ketamine IM dose is

A

4-8 mg/kg

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8
Q

Ketamine PO dose is

A

10mg/kg

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9
Q

Low dose OPIOD sparing effect of Ketamine

A

0.1 - 0.3mcg/kg/min

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10
Q

What is the intubation dose of Rocuronium?

A

0.6 - 1.2mg/kg

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11
Q

Atracurium intubation dosage

A

0.5 mg/kg

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12
Q

Cisatracurium intubation dosage

A

0.1 mg/kg

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13
Q

Neosynephrine (phenylepherine) infusion rate range?

A

0.15–0.75 µg⋅kg/min

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14
Q

Norepinephrine infusion rate

A

Start 0.01  µg⋅kg/min then titrate to effect

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15
Q

Vasopressin

A

0.01–0.04 units⋅min−1

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16
Q

Beta only dose EPI

A

0.01–0.03 µg⋅kg−1⋅min−1

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17
Q

Alpha and Beta EPI dose

A

0.03–0.1 µg⋅kg−1⋅min−1

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18
Q

Alpha and Beta EPI dose

A

0.03–0.1 µg⋅kg−1⋅min−1

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19
Q

More alpha Epi dose

A

> 0.1  µg⋅kg−1⋅min−1

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20
Q

Nitroprusside

A

0.5–10 µg/kg/min (bolus 1–2 µg/kg)

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21
Q

Nicardipine

A

5–15 mg/hr

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22
Q

Nitroglycerin

A

Initial infusion rate is typically 5 to 10 µg/min, and it is titrated in additional increments of 5 to 10 µg/min every 10 min to effect.

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23
Q

Diltiazem : intravenously as a bolus dose of

A

0.25 mg/kg, followed by a continuous infusion of 5 to 15 mg/min for the treatment of supraventricular tachycardia or atrial arrhythmias.

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24
Q

Dobutamine

A

2–20 µg⋅kg/min

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25
Q

Milrinone

A

Loading dose of 20–50 µg⋅min–1, then 0.25–0.75 µg⋅kg–1⋅min–1

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26
Q

Isoproterenol

A

> 0.15 µg⋅kg/min

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27
Q

Ephedrine

A

5mg IVP for hypotension

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28
Q

Metoprolol

A

5mg IVP

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29
Q

Succinylcholine
Low dose
High dose

A

1-2 mg/kg

3-4 mg/kg

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30
Q

Atropine dose for Bradycardia

A

0.5 mg Every 3-5 minutes

Max is 3 mg

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31
Q

Ondansetran

A

4mg IV , 8mg Max for cardiac

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32
Q

Naloxone (Narcan dose)
How do you mix
Duration is
half life

A 
0.4mg in mL
Aspirate the 1ml from vial add to 9ml of NS
give you 40mcg/ml
30-45 mns
1 hour
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33
Q

Calcium Chloride

A

20mg/kg for CCB and Beta Blockers overdose

Cardiac arrest 1-2g

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34
Q

Vecuronium

A

0.8-1.2mg/kg

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35
Q

Esmolol

A

500mcg/kg loading dose over 1 min followed by 50

mcg/kg/min infusion for 4 mins

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36
Q

Flumazenil

A

0.2 mg q 2min Max 1 mg

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37
Q

Glucagon

A

1mg q15 min

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38
Q

Calcium Chloride 2 uses and doses

A

20mg/kg for CCB and Beta Blockers overdose

Cardiac arrest 1-2g

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39
Q

Precedex

A

1mcg/kg

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40
Q

Sevo MAC

A

0.65

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41
Q

Des MAC

A

6.6

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42
Q

N2O

A

104

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43
Q

Albuterol class and use

A

Beta Adrenergic agonists, most potent bronchodilator, for asthma and COPD

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44
Q

Ipratropium

A

Anticholinergic , superior to SABA in patients with COPD

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45
Q

Dopamine (dosing scheme)
onset
Peak
Duration

A 
D B A
Dopamine  Dose 2-5 mcg/kg/min
Beta Dose Dose 5-10 mcg/kg/min
Alpha dose 10-20 mcg/kg/min
Half life : 2 min
O 5 min
P
D  <10min
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46
Q

Ephedrine

A

synthetic non-catecholamine
5 mg
Require 250X than epinephrine for the same response
LAST LONGER

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47
Q

Epinephrine

A

1ml in 250 ml bag –> 4 mcg/ml

Drips is 1-16 mcg/kg/min

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48
Q

Glycopyrolate

A

0.01 - 0.02mg/kg IV

REVERSAL (0.2mg per 1 mg of Neostigmine)

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49
Q

Neostigmine

A
  1. 04mg/kg for 2 TOF twitches

0. 07 mg/kg for 4 TOF twitches

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50
Q 
Nitroglycerine
what about nipride?
Concentration is 
Initial start dose
How to titrate?
A 
Venous dilator 
Nipride dilates both 
25 mg in 250 ml bottle
INITIAL DOSE IS 0.2 mcg/kg/min
Titrate 0.1mcg /kg/min q3-5min
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51
Q

Nitroprusside
Concentration
Dose
Toxicity

A

Arteriolar and veno vasodilator
50 mg in 250 ml
0.25- 5 mcg/kg/min
Thiocynate Toxicity with > 3 mcg/kg/min

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52
Q

Norepinephrine
Initial dose
Bag concentration
Alpha vs Beta

A

8mcg/min, titrate 2mcg/min q 5mins
4 mg in 250 ml = 16mcg/ml
8 mg in 250 ml = 32 mcg/ml
ALPHA > BETA

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53
Q

Phenylephrine
Most common infusion rate appears to be
SPECIAL Because

Effects on blood flow

A

40-80mcg/min

Increases both arterial and venous blood vessels increasing SVR without changing cardiac dynamics.
Decrease Blood flow to all organs
Do not give with BRADYCARDIA cause it slows the HR

54
Q

Alfentanil onset , peak , potency, duration, induction dose and intubation dose.

A

Onset is 1.4 minutes , 3-5 minutes
Duration 30-60 minutes
Less potent than remifentanyl, less apnea than remifentanyl
Induction dose is 15 mcg/kg before direct laryngoscopy
Intubation dose is 30mcg/kg to BLOCK the catecholamine response.

55
Q 
FENTANYL
Equivalence to morphine
Onset and duration
Lipid solubility
Half life
Metabolism
Excretion
May cause this?
A 
Most common use
100x more potent than morphine 
Rapid onset and short duration of action , 30-60mins
Highly lipid soluble
2-4 hours
Metabolism: Liver 
Excretion : Kidneys 
Chest wall rigidity
56
Q

Hydromorphone
Dose, onset, duration, potency when compared to morphine
Receptors.
Contraindications

A 
Status asthmaticus, Increased ICP and intracranial lesions. 
Mu and Kappa 
0.5 to 1 mg/hr IVP 
2-5 min onset
Duration 2-4 hours
Half life is 2.3 hours
57
Q

Labetalol
Clinical dose
Beta to alpha ratio is (oral or IV)
Half time is _______

A

10-20 mg q10 mins

7: 1 IV
3: 1 oral

58
Q

Metoprolol

A

k

59
Q

Remifentanyl: Potency
Onset, peak, duration,dose, solubility
Always use as a

A 
19 x more potent than alfentan
Rapid and Ultra short duration of action
Onset 1.1 minutes
Peak 2 minutes
Less soluble than other 
1-3 mcg/kg over 1 minute
Continuous drip
60
Q

Sodium Bicarbonate

A

Cardiac arrest 1 meq/kg/dose

For metabolic acidosis with ph<1

61
Q

Induction dose of Esmolol

Induction dose is ____

A

Rapid onset, short duration of action
0.5mg/kg over 1 min
Induction 100-150mg 2 min before laryngoscopy

62
Q

When mixing phenylephrine: BAG mixing

A 
Mix 10 mg vial in 250 ml of NS or D5W = 40 mcg/ml 
Mix 2 (10mg) vials in 250 ml of NS or D5W= 80mcg/ml
63
Q

Half life for propofol infusion up to 8hrs

A

<40 minutes

64
Q

Propofol is metabolized by

active metabolites?

A

Glucuronidation in the liver into inactive metabolites

no

65
Q

Propofol time to peak

A

90-100 second (2mns)

66
Q

Propofol onset

A

30 seconds

67
Q

Propofol protein binding

A

98%

68
Q

Vd of propofol

A

3-4L/kg

69
Q

Propofol is made up of

A

Soybean oil
glycerol
egg

70
Q

Propofol acid or base

A

Acid pka 11

71
Q

Succinylcholine dose

A

0.5 - 1 mg/kg

72
Q

Succinylcholine onset

A

30-60 sec

73
Q

Succinylcholine Duration

A

3-5 minutes

74
Q

Succinylcholine metabolism

A

Plasma cholinesterase

75
Q

Side effects of succinylcholine

A

Bradycardia (most likely to be seen with a second dose)

76
Q

How much do succ increase K

A

0.5 mEq

77
Q

People who can metabolize succ

A

Atypical cholinesterase

78
Q

Test done for people with atypical cholinesterase is

A

Dibucaine test

79
Q

Normal dibucaine test is

A

80% (inhibit activity of plasma cholinesterase by 80%

80
Q

Heterozygous dibucaine

A

40-60

81
Q

homozygous dibucaine

A

20

82
Q

Dibucaine number only refer to ____Not ____

A

Quality not quantity

83
Q

What pressure do succinylcholine increases

A

IOP (ocular)
IAP (abdominal)
ICP (cranial)

84
Q

Rocuronium onset

A

1-2 minutes

85
Q

Rocuronium PEAK

A

60-90 seconds

86
Q

Rocuronium duration

A

20-35 minutes

87
Q

Rocuronium excretion

A

liver 70%

Renal 30%

88
Q

Etomidate intubation dose

A

0.3-0.6mg/kg

89
Q

Etomidate onset

A

30-60 seconds

90
Q

Etomidate peak

A

1 minutes

91
Q

Etomidate duration

A

3-10 minutes

92
Q

Etomidate half time

A

2-5 hours

93
Q

Etomidate Protein binding

A

76%

94
Q

Limiting factor of etomidate

A

Adrenocortical function depression

PONV

95
Q

ADvantage of etomidate

A

minimal changes with hemodynamics

96
Q

How does etomidate causes adrenocortical suppresion?

A

Inhibits the enzyme 11-beta hydroxylase for 4-8 hours after induction. That enzyme converts cholesterol to cortisol, which patient needs to properly response to stress.

97
Q

Ketamine causes at post op

A

Emergence delirium

98
Q

Ketamine and airway

A

upper airway reflexes remain intact

99
Q

Ketamine active metabolites

A

Yes , norketamine 1/3 as potent

100
Q

Ketamine and bronchioles

A

Bronchodilation

101
Q

Ketamine class

A

Binds noncompetitively to NMDA receptor

102
Q

Ketamine onset

A

30 seconds

103
Q

Ketamine peak

A

3-5 minutes

104
Q

Ketamine duration

A

8-15 minutes

105
Q

Vecuronium class

A

Monoquartery aminosteroid

106
Q

Vecuronium intubation dose

A

0.08-0.1 mg/kg

107
Q

Vecuronium onset

A

3-5 minutes

108
Q

Vecuronium peak

A

3-5 minutes

109
Q

Vecuronium duration

A

20-35 minutes

110
Q

Vecuronium excretion

A

Liver 80%

Kidney 20%

111
Q

Rocuronium class

A

Monoquartery aminosteroid

112
Q

Cistracurium class

A

benzylisoquinolinium

113
Q

CisAtracurium other name

A

Nimbex

114
Q

Cisatracurium onset

A

1-5 minutes

115
Q

Cisatracurium peak

A

3-5 minutes

116
Q

Cisatracurium duration

A

25-35 minutes

117
Q

Cisatracurium metabolims

A

Hoffman elimination

118
Q

Cisatracurium metabolites

A

Laudnosine

119
Q

Cistatracurium metabolizes to laudanosine which can cause

A

Seizures.

120
Q

Duramorph is

A

derivatives free morphine

121
Q

Duramorph intrathecal dose is

A

0.1-0.5 mg

122
Q

Bupivacaine onset is

A

FAST

123
Q

Max dose bupi without epi

A

175 mg (70 mls)

124
Q

Max dose bupi with epi

A

225 ml (90mls)

125
Q

Bupivacaine duration is

A

2-8 hours

126
Q

Bupivacaine class

A

amide LA

127
Q

What is the ED95 dose of Rocuronium?

A

0.3mg/kg

128
Q

What is the ED95 dose of succinylcholine?

A

0.3mg/kg

129
Q

What is the ED95 dose of Atracurium?

A

0.25mg/kg

130
Q

What is the ED95 dose of Cisatracurium?

A

0.05mg/kg

131
Q

What is the ED95 dose of Vecuronium?

A

0.05mg/kg

SRNAClinical Practicuum Prep (21 decks)

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