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Psychological Disorders > Dopamine theory of SZ > Flashcards

Dopamine theory of SZ Flashcards

1
Q

Carlsson+ Lindquist (1963)

A

phenylthiazines decreased SZ symptoms
(intended as antihistamines)
chlorpromazine
Geddes (2001)= therefore SZ= increased dopamine

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2
Q

Haddad+ Mattay (2011)

A

typical antipsychotics cause PD-like symptoms (further support for dopamine theory)

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3
Q

McGuire (2008)

A

higher dopamine release during psychosis

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4
Q

Owen (1978)

A

more dopamine receptors in SZ patients

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5
Q

Seeman (1984)

A

2 subtypes of SZ

25% increase or 240% increase in D2 receptors

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6
Q

Wong (1986)

A

fMRI scans show increased receptor density

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7
Q

Seeman+ Van Tol (1994)

A

D1-4 subtypes

D4 increased by 600%

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8
Q

Howes (2013)

A

higher tyrosine hydroxylase

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9
Q

Cross (1981)

A

due to increase in D2, not D1 receptors

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10
Q

Krystal (2013)

A

amphetamines, cocaine and L-dopa increase dopamine/ lead to psychosis

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11
Q

Beaulieu- Boire

A

L-dopa increases dopamine, 30% get psychotic reactions

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12
Q

Snyder (1997)

A

D2 receptor affinity increases efficacy (strong correlation)

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13
Q

Farde (1987)

A

didn’t find changes in D2 density

though Seeman+ van Tol (1994) said they had flawed methodology

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14
Q

Howes (2015)

A

glutamate involved instead

drugs acting on NMDA receptors= psychosis

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15
Q

Weinberger (1982)

A

ventricular enlargement to blame

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16
Q

Thompson (2001)

A

less neurons/ grey matter

17
Q

Kystal (2003)

A

NMDA agonists cause psychosis

indicates role of glutamate

18
Q

Seeman+ van Tol (1994)

A

D4-specific antagonists have no effect

19
Q

Reynolds

A

chlorpromazine (atypical) has good affinity for D2 and 5-HT receptors
?role of 5-HT

20
Q

Leonard (2003)

A

atypical drugs work much better on both positive and negative symptoms

21
Q

typical antipsychotics can make what type of SZ worse?

A 
type 2
(frontal lobe)

Psychological Disorders (7 decks)

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