dopamine hypothesis and neurotransmitters Flashcards
what does the dopamine hypothesis suggest
that schizophrenia is a result of excess dopamine
what is their an increase in to cuase symptoms
sensitivity an density
where does this increase of sensitivity and density occour
at the synapses
what does this increase in sensitivity lead to
increase activity of dopamine at the synapses
what are schizophrenics more likely to pick up
dopamine
schizophrenics have a higher number of what
d2 sites
where does overstimulation happen
mesolimbic pathway
what does too much dopamine in the mesolimbic pathway lead to
positive symptoms
what leads to negative symptoms
too little dopamine in the mesocortiol pathway
give supporting research for the dopamine hypothesis
carlsson et al
brain scanning shows that if those with schizophrenia are given amphetamines. greater relase of dopamine than those without schizophrenics took it.
t/f suggests those with schizophrenia more sensative to excess dopamine.
give the name of anouther supporting research
wong et al
what did Wong et al find
PET scans show greater density of dopamine receptors in unmedicated compared to medicated schizophrenics
t/f suggests that density of dopmaine receptors does contributr to increased activity and schizophrenic symptoms
name one weakness of the dopamine hypothesis to explain schizophrenia
it is reductionist
define the reductionist point
theory only considers the role of the neurotransmitter dopamine and these abnormalities have not been found in all schizophrenics. social and enviromental factors have been found to trigger schizophrenia and the role of neurotransmiiters does not account for this
t/f a biological explination does not account for nurture and so is not a holistic explination of schizophrenia
give the name of supporting research that down plays schizophrenia
jackson
explain jacksons supporting research
reviewd evidance from various studies found no consistant differences between level of dopamine in untreated schizophrenics and control group
t/f casting doubt on role of dopamine in development of schizophrenic symptoms
what are the three neurotransmitters used to explain schizophrenia
dopamine
glutimate
seretonin
what do low levels of glutimate corrispond to
high levels of dopamine
why does this occour
because glutiate inhibits dopamine
give one place glutimate failure occours
cerbral cortex
what does glutimate failure in the cerbral cortex lead to
negative symptoms
give an example of a negative symptom
inappropriate emotions
give anouther place glutimate failure occours
basal gangalia
what does failure in the basal ganglia lead to
positive symptoms
give an example of a positive symptom
delusions
what are high levels of serotonin linked to
positive symptoms
what condition produces glutermate
hypoglutametergenic
what is anouther supporting point
seeman
what did seeman find
increased density of dopamine D2 receptors in postmortem brain of schizophrenia suffers
what is anouther supporting research
amphetamine users research
what does the role of amphetamines play in schizophrenia
showed that aphjetamine users had similar symptoms to schizophrenics becuase the drug causes an increase in dopamine
