DMARDs Flashcards
1
Q
What class of drug is Azathioprine?
A
Non-biologic disease-modifying anti-rheumatic drug
2
Q
What are the common indications of Azathioprine?
A
SLE and vasculitis
RA- very weak evidence
Inflammatory bowel disease (Crohn’s and UC)
3
Q
What is the mechanism of action of Azathioprine?
A
Cleaved to 6-MP. Anti-metabolite which decreases DNA and RNA synthesis.
4
Q
What are the adverse effects of Azathioprine?
A
Bone marrow suppression
Increased risk of malignancy
Increased risk of infection
Hepatitis
5
Q
What are the drug-drug interactions of Azathioprine?
A
Certain cancer drugs (Cyclophosphamide)
Drugs that weaken the immune system (Rituximab)
6
Q
How can you remember Azathioprine?
A
