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Drug Of The Day > Diuretics > Flashcards

Diuretics Flashcards

1
Q

What class of drug is Indapamide?

A

Thiazide like diuretic

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2
Q

Drugs that are thiazide like diuretics?

A

Indapamide and Bendroflumethiazide

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3
Q

Indications of Indapamide

A

Antihypertensive

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4
Q

Mechanism of action of Indapamide

A

Inhibits Na/Cl co-transporter in the distal tubule

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5
Q

Adverse effects of Indapamide

A

Hyperuricaemia, Hyperglycaemia, ED, increase in LDL, increase in triglycerides, Hypercalcaemia, Hypokalaemia

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6
Q

Contra-indications of Indapamide

A

Addison’s disease, Hypercalcaemia, Hyponatremia, Refractory hypokalaemia, symptomatic hyperuricaemia

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7
Q

Drug-drug interactions of Indapamide

A

Alcohol and Amlodipine
quite commonly given together to help treat hypotension

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8
Q

Why do you take Indapamide in the morning as a single dose?

A

So you don’t have to get up in the night to wee

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9
Q

How do you remember Indapamide?

A
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10
Q

What type of drug class is Spironolactotne?

A

Potassium sparing diuretic

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11
Q

What are the common indications of Spironolactone?

A

Heart failure

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12
Q

What is the mechanism of action of Spironolactone?

A

Mineralocorticoid receptor antagonist ,aldosterone antagonist

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13
Q

What are the adverse drug reactions of Spironolactone?

A

Gynaecomastia, hyperkalaemia, cutaneous adverse reaction

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14
Q

What are important drug-drug interactions of Spironolactone?

A

Alcohol, Amiloride and ACEi

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15
Q

How do you remember Spironolactone?

A

Holding bananas- potassium sparing
Minions won’t drink alcohol (drug-drug interaction)
Together look like two boobs (gynaecomastia)

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16
Q

what diuretics fall under ADH antagonists

A

conivaptan/tolvaptan

17
Q

how do ADH antagonists work

A

they interfere with binding of ADH in collecting duct and alter the expression of AQP2 in principal cells

18
Q

what are some side effects of ADH antagonists

A

hyponatraemia

19
Q

which drug class reduces the effect of diuretics and why

A

NSAIDS
they inhibit prostaglandin synthesis and so cause sodium and water retention

20
Q

which diuretic drug class is used specifically in glaucoma

A

carbonic anhydrase inhibitors
acetazolamide
methazolamide

21
Q

how do carbonic anhydrase inhibitors work

A
  • they inhibit the reabsorption of bicarbonate in the pct so bicarbonate remains in the tubule
22
Q

which specific diuretic is used when there is a rise in intracerebral pressure

A

mannitol

23
Q

how does mannitol work

A

it is an osmotic diuretic and so draws water into the tubule

24
Q

what is the drug class of furosemide or bumetanide

A

loop diuretics
they inhibit the NaKClC2
so reduced reabsorption of NaCl in the thick ascending loop of henley

Drug Of The Day (16 decks)

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