Diabetic Drugs Flashcards
What class of drug is Dapagliflozin?
Sodium-glucose co-transporter inhibitor
What are the indications of Dapagliflozin?
Add on therapy to type 2 diabetes mellitus. HFrEF and reduced kidney function
does dapagliflozin have some diuretic effect
minor
What is the mechanism of action of Dapagliflozin?
Decreases glucose reabsorption from tubular filtrate. Increases urinary glucose excretion. Competitive reversible inhibition of SGLT-2 in PCT.
What are the adverse effects of Dapagliflozin?
UTI, thirst, polyuria and pancreatitis
What are the drug-drug interactions of Dapagliflozin?
Antihypertensive and other hypoglycaemic agents
What can you use to remember Dapagliflozin?
What is the class of Semaglutide?
Incretin mimetic
What are the indications for Semaglutide?
TIIDM + weight loss
Mechanism of action of Semaglutide
Increase glucose dependent synthesis of insulin secretion.
GLP-1 receptor agonist
Because of how they are made they are resistant to DPP-4
What are the adverse effects of Semaglutide?
GI upset, decreased appetite with weight loss
What can you use to remember Semaglutide?
