Anticoagulants Flashcards
1
Q
What class of drug is Apixaban?
A
Direct acting oral anticoagulant (DOAC)
2
Q
What are the common indications for Apixaban?
A
DVT or PE
3
Q
What is the mechanism of action of Apixaban?
A
Inhibit both free Xa and that bound with ATIII, do not directly affect thrombin (IIa)
Hepatic metabolism and excreted partly by kidneys
4
Q
What are the adverse effects of Apixaban?
A
Bleeding and skin reactions
5
Q
What are the drug-drug interactions of Apixaban?
A
CYP inhibitors and inducers
Reduced by carbamazepine, phenytoin and barbituates
Increased by macrolides
6
Q
How do you remember Apixaban?
A
7
Q
What class of drug is Dalteparin?
A
Low molecular weight heparin
8
Q
What are the drug-drug interactions of Dalteparin?
A
Other anti-thrombotic drugs, ACEi/ARB, K+ sparing diuretics
