DL/DS Swollen Joints Flashcards

1
Q

Pattern spotting :
3mo foal, v lame LF, multiple swollen joints - hot, effusive and painful, 3w prior foal tx with short course Abx for cough/fever/^RR

A
  • suspect septic arthritits (pyrexic complaint previously, acute onset)
    > arthrocentesis, joint fluid analysis, C+S
  • leukocyte count >30,000 cells/uL >90% neutrophils and elevated TP >2.5g/dl
  • culture results may be negative (use blood culture medium or synovial biopsy to ^ accuracy)
    > radiograpohy repeated weekly
  • normal initially
  • lysis few days after onset
  • presence of osteomyelittis afects Px and Tx
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2
Q

Logical approach:
3mo foal, v lame LF, multiple swollen joints - hot, effusive and painful, 3w prior foal tx with short course Abx for cough/fever/^RR

A
> young animal systemic problem 
- 3mo, multiple swollen joints
> acute problem serious nature
- hot, effusive, painful joints, very lame
> possible infectious hx
- resp infection 
>> PLAN
- biochem/haem to r/o systemic problem 
- arthrocentesis, joint fluid abnalysis, C+S, radiography
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3
Q

Tx septic arthritis foals?

A

> emergency!
- tx BS Abx while waiting for C+S(cephalosporin or panicillin/aminoglycoside combo eg. pen and gent) IV or IA
- joint lavage
- resample joint fluid q48hrs
management
- minimising joint movement helps reduce damage but passive movment may minimise fibrin adhesion
- box rest and supportive bandaging, physiotherapy

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4
Q

Px septic arthritits foals?

A
  • Prompt recogniition, aggressive Tx and local ABx = improved px
  • multiple istes of involvement = ^ risk of poor future atheltic performance
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5
Q

> define and refine:

  • sudden onset lameness 10 landraceX gilts large commercial unit, msot lame single HL, bilateral sweeling tarsus, one animal recumbent.
  • all animals from group brought in 9d ago @110kg breeding replacemenet
  • pigs housed in a yard system on solid floors
A
  • group of pigs, likely infectiou s
  • replacement gilts underweight, unlikely to be DJD
  • pigs show different clinical signs: disease is progressive
  • solid floor: risk of trauma? multiple pigs affected concurrently though.
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6
Q

> DXx

  • sudden onset lameness 10 landraceX gilts large commercial unit, msot lame single HL, bilateral sweeling tarsus, one animal recumbent.
  • all animals from group brought in 9d ago @110kg breeding replacemenet
  • pigs housed in a yard system on solid floors
A
  • isolate new pigs and incontact
  • synovial fluid sample and cultre
  • temperature if raised suspect infection
  • cull most severely infected (recumbent) PM
  • rads and ultrasound not possible $$$$$
  • Ab assay on bloods for common diseases
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7
Q

Ddx:

  • sudden onset lameness 10 landraceX gilts large commercial unit, msot lame single HL, bilateral sweeling tarsus, one animal recumbent.
  • all animals from group brought in 9d ago @110kg breeding replacemenet
  • pigs housed in a yard system on solid floors
A
  • mycoplasma hyosynoviae infection
  • DJD
  • Erysipelas infection
  • Glassers disease
  • Trauma
    > See ppt for good table
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8
Q

Tx mycoplasma hyosynoviae?

A
  • lincamycin/tiamulin

- prevention: in feed medication, lower stress, resp spread control

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9
Q

> Dxx:

  • 2yo TB racehorse
  • acute onset, mod LF lame after gallop, heat and effusion @ carpus, + response to felxion of carpus
A
  • rads (both limbs, bilateral dz common)
  • joint block
  • arthroscopy
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10
Q

What would be seen on rads concurretnly with a carpal chip fx?

A
  • joint effusion

- osteophyte formation poss

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11
Q

Pathogenesis of carpal chip fx?

A
  • cumulative microdamage d/t repetitive loading
  • loss of smooth articular surface, OCD fragments -> synovitis, effusion and pain
  • chronic release of MMPs, enzymes and catalytic enzymes may -> DJD and OA
  • OA and fibrosis of joint capsulle restrict ROM and perfomrance
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12
Q

Tx carpal chip fx?

A
  • standing arthroscopic sx to remove chip and debride joint
  • +- lavage
  • skin sutures
  • NSAIDS
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13
Q

pX CARPAL CHIP FX?

A
  • most common fx in racehorses (2nd most common intercarpal joints)
  • px excellent
  • px worsens with chronicity and loss of cartilage
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14
Q

Most common site of carpal chip fx?

A
  • craniodistal intermediate carpal bone
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15
Q

Dxx:

  • 5yo DSH cat
  • 4wk hx lethargy, not going outside esp morning
  • acute lameness LH, swollen hot effusive left tarsus and swollen R tarsus and carpus
A
  • radiographs
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16
Q

Differnetials for cat 4 week hx lethargy, acute LH lame, swollen hot carpus and tarsi, joint effusion L tarsus
+ large amounts new bone formation at tarsus
- joint ankylosis?
> next steps?

A
  • periosteal proliferative polyarthritis
  • feline chronic progressive polyarthritis
  • septic arthrittis (bacterial normally one limb)
  • OA/ osteosarc/ Osteomyelitis
    > next steps
  • analgesia (NSAIDs, corticosteroids CI d/t infection as ddx)
  • arthrocentesis (cell count, cyto, culture - decide inflammatory? -> septic? may need serology)
  • ham/biochem in case systemic
17
Q

Price for full joint investigation in a cat?

A

> £600

18
Q

What is periosteal proliferative arthritis? Tx? Px?

A
  • idiopathic inflammatory arthritis
  • linked to FeLV, FIV, FeSFV
    > Tx: prednisolone @ immunosuppressive doses, + cyclophosphamide
  • monitor response w/ WBC cytology for 2* infections (+- Abx)
  • Physio to improve ROM
    > Px guarded - poor
  • euthanasia on humane grounds if joint deformity severe
19
Q

Use and Is azathioprine CI for anythign?

A

CATS! (commonly used as 2* tx for IMPA in dogs)

- BM suppression -> non-responsive severe fatal leucopenia and thrombocytopenia

20
Q

Dxx:

  • 8yo black lab, ME 39kg
  • intermitten FL lame over the years, NSAIDs successful, presented for 4/10 LF lame 2 weeks ago nonresponsive to NSAIDs
  • restriction on fleion and extension both elbows, worse R
  • no pain
A
  • radiographs
21
Q

How can inflammaotry and non-inflammaotry joitns be distinguished?

A
  • Arthrocentesis
  • haem: WBC >3000/ul = inflammatory
  • cytology: mononuclear/PMNCs (degenerate or not), intracellular bacteria (rare), macrophages w/ DJD
  • culture: blood culture medium, r/o immune mediated dz
  • appearance: viscosity, colour, elasticity, clarity
22
Q

Ddx:

  • 8yo black lab, ME 39kg
  • intermitten FL lame over the years, NSAIDs successful, presented for 4/10 LF lame 2 weeks ago nonresponsive to NSAIDs
  • restriction on fleion and extension both elbows, worse R
  • no pain
A
  • Non-inflammaotry DJD

- Inflam immune-mediated non-erosive PA eg. SLE, idiopathic PA

23
Q

What is seen on arthrocentesis with DJD?

A

Macrophages high but WBCs low

24
Q

Tx DJD/ OA?

A
  • ^ dose NSAIDs/switch to different
  • Tramadol/ACP
  • anti-inflammaotry corticosteroid doses
  • GAGs, HA
  • short regular excercise
  • hydro/physio
25
Q

Ddx:
3yo M green iguana
- abnormal HL gait esp RH, movement stifle limiteed
- hard swelling right stifle, animal resists manipulation of this joint +- left stifle swelling and pain
- balanced mixed diet, UV ok

A

> Gout
- 1: accumulatino of urate crystal in organs and joints d/t chronic hyperuricemia d/t excess protein in the diet
- 2
: d/t chronic hyuperuricemia d/t renal insufficiency/dehydration
Pseudo-gout
- deposition of other crystals not uric acid
MBD
- 2* nutritional hyperparathyroidism (most common reptile, d/t poor diet Ca:P ratio or Vit D3 deficiency or poor husbandry UVB light or heat
- 2* renal hyperparathyroidism d/t renal dz
Immune mediated
inflam/infectious
- abscess
fx

26
Q

How would gout appear on radiogrpahs?

A
  • mineralisation of affected joints

- calcium deposits can be left along with uric acid crystal s

27
Q

How would MBD appear on radiographs?

A

generlised demineralisation of the skeleton

28
Q

Further investigation for
3yo M green iguana
- abnormal HL gait esp RH, movement stifle limiteed
- hard swelling right stifle, animal resists manipulation of this joint +- left stifle swelling and pain
- balanced mixed diet, UV ok

A

> radiographs
bloods
- hydration status
- 2* nurtiional HPT -> low plasma 25-dihydroxycholecalciferol +- hypophosphataemia, hypocalcaemia and signs of reduced renal function
biochem
- gout: ^ uric acid in blood
arthrocentesis
- septic v immune mediated (degenerate neutrophils)
urinalysis
- haematuria/WBCs/renal casts with renal dz

29
Q

Is USG in reptiles useful for assessing renal function?

A

Noooo because filtrate is isostheneuric so changes in kidney function are not reflected in USG

30
Q

Tx gout?

A
> pain releif 
- NSAIDs
- monitor for GI side effects
> diet
- 1* gout reduce/eliminate highprotein foods in diet 
> rehudration 
- 2* gout 
- water baths, fluid therapy, moist food
> allopurinol 
- reduces blood uric acid levels 
- LONGTERM not during acute outbreak 
- will relaspe if taken off 
> euthanasia if apetitie suppressed and painful
31
Q

How can gout and pseudogout be differentiated?

A

> Gout
- hyperuricemia on biochem
- radiogrpahic changes eroisons and overhangs
- needle shaped crystals in synovial fluid
pseudogout
- radio-opaque mineral in/around joints
- hypercalcaemia on biochem
- rhomboid shaped crystals in synovial fluid

32
Q

Whichi NSAIDs ccan be used in reptiles?

A

lack of evidence

  • NSAIDS (ketoprofen)
  • butorphanol
  • morphine
33
Q

Which pathogen is commonly present in pigs but is usually subclinical and not cnecessarily the cause of disease?

A
  • Mycoplasma and Glassers
34
Q

What is periosteal proliferative arthritis the equivalent dz in dogs?

A

Rheumatoid arthritis