Diuretic Drugs Flashcards
diuretic drugs
make high vol of urine/liquid
all dec blood vol and dec blood pressure
dec BP reversed by
activating RAS (renin-angiotensin system) inc cardiac output vasoconstriction
dec blood P effect in body and drug
dec renal bloof flow
dec glomerular filtration rate
dec urine vol
reduce drug excretion (as a result of dec urine vol)
inc urine vol (on body and drug)
Body: dec blood vol dec edema dec blood p dec work done by heart
Drug: inc drug excretion dec therapeutic drug effects (peeing out drug) dec overdose drug effects
inc pH urine
inc excretion of w.acid drugs
maintain kidney function
need to keep kidney working to prevent anuria
diuretic useful
K (potassium) wasting diuretics: thiazides
mech of action
drugs
inc urine K, block Na and H2O reabsorption
- hydro-chloro-thiazide
- tri-chlor-me-thiazide
K (potassium) wasting diuretics: high ceiling diuretics: loop diuretics
mech of action
drugs
inc urine vol, block Na and H2O reabsorption
inc Na, K, Cl, Mg, Ca excretion
- furo-semide
- etha-crynic acid
K sparing diuretics
mech of action
drugs
inc Na and H2O excretion, block pores that reabsorb Na
- spiro-no-lactone
- eple-renone
- ami-loride
- triam-terene
carbonic anhydrase inhibitors
mech of action
drugs
block CA (carbonic anhydrase) activity CA = catalyze/decompose carbonic acid to CO2 + H2O
inc urine
inc H2O and HCO3 excretion
dec H and K excretion
inc urine pH, dec plasma pH
-aceta-zolamide
extra-renal diuretics: osmotic diuretics
mech of action
drugs
inc urine production
inc blood vol/flow (take water from cells to extracellular space)
inc Na, K Cl excretion
-mannitol
extra-renal diuretics: ACE inhibitors
mech of action
drugs
inc urine production
dec aldosterone secretion/effect (block plasma angiotensin II synthesis)
inc blood vol/flow
inc Na excretion
- capto-pril
- benaze-pril
- lisino-pril
