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PHM Exam 2 > Cardiac Dysfunction Angina Drugs > Flashcards

Cardiac Dysfunction Angina Drugs Flashcards

1
Q

Amyl nitrite

A
  • Organic Nitrates (provide NO)
  • inc cGMP
  • inc blood flow
  • resolve O2 deficiency

Extra-cardiac Actions

  • dec preload and afterload
  • dec bp
  • dec CO
  • dec workload
  • dec O2 demand of heart
  • O2 deficit resolution
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2
Q

Nitroglycerin

A
  • Organic Nitrates (provide NO)
  • inc cGMP
  • inc blood flow
  • resolve O2 deficiency

Extra-cardiac Actions

  • dec preload and afterload
  • dec bp
  • dec CO
  • dec workload
  • dec O2 demand of heart
  • O2 deficit resolution
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3
Q

Isosorbide dinitrate

A
  • Organic Nitrates (provide NO)
  • inc cGMP
  • inc blood flow
  • resolve O2 deficiency

Extra-cardiac Actions

  • dec preload and afterload
  • dec bp
  • dec CO
  • dec workload
  • dec O2 demand of heart
  • O2 deficit resolution
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4
Q

Verapamil

A 
Ca Channel Blockers
Heart:
- dec Ca influx into ventricular cells
- dec contractility - dec CO - dec bp
- dec workload of heart
- dec O2 demand on heart
- resolution of O2 deficit

Vascular:

  • vasodilation
  • dec afterload - dec bp
  • dec work done by heart
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5
Q

Diltiazem

A 
Ca Channel Blockers
Heart:
- dec Ca influx into ventricular cells
- dec contractility - dec CO - dec bp
- dec workload of heart
- dec O2 demand on heart
- resolution of O2 deficit

Vascular:

  • vasodilation
  • dec afterload - dec bp
  • dec work done by heart
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6
Q

Nifedipine

A 
Ca Channel Blockers
Heart:
- dec Ca influx into ventricular cells
- dec contractility - dec CO - dec bp
- dec workload of heart
- dec O2 demand on heart
- resolution of O2 deficit

Vascular:

  • vasodilation
  • dec afterload - dec bp
  • dec work done by heart
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7
Q

Amlodipine

A 
Ca Channel Blockers
Heart:
- dec Ca influx into ventricular cells
- dec contractility - dec CO - dec bp
- dec workload of heart
- dec O2 demand on heart
- resolution of O2 deficit

Vascular:

  • vasodilation
  • dec afterload - dec bp
  • dec work done by heart
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8
Q

Atenolol

A

β1 adrenergic Blocking agent

  • dec HR
  • dec work by heart - dec O2 demand
  • resolution to O2 deficit
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9
Q

Metaprolol

A

β1-adrenergic Blocking agent

  • dec HR
  • dec work by heart - dec O2 demand
  • resolution to O2 deficit
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10
Q

Pindolol

A

β1 adrenergic Blocking agent

  • dec HR
  • dec work by heart - dec O2 demand
  • resolution to O2 deficit
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11
Q

Propranolol

A

β1 & β2 adrenergic Blocking agent

  • dec HR
  • dec work by heart - dec O2 demand
  • resolution to O2 deficit
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12
Q

β-blocker and nitrate or Ca channel blocker

A

Drug Combinations
- β-blocker prevent reflex tachycardia (good, slow speed, inc heart work)
- β2 antagonists will vasoconstrict (bad, inc R, inc bp, inc heart work)
- Nitrate will vasodilate (good)
Additive Effect

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13
Q

Nitrate and Ca channel blocker

A

Drug Combinations
- nitrate = dec preload
- Ca blocker = dec afterload
Additive Effect

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PHM Exam 2 (10 decks)

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