Blood Glucose Drugs

Question 1

Tolbutamide

Answer 1

Hypoglycemic compounds:
Sulfonylurea receptor activator (Inducers of Insulin Secretion)
Useful only in Type II (NIDD)
- inc insulin release - dec plasma glucose
- effective if insulin “resistance” absent

Question 2

Glyburide

Answer 2

Hypoglycemic compounds:
Sulfonylurea receptor activator (Inducers of Insulin Secretion)
Useful only in Type II (NIDD)
- inc insulin release - dec plasma glucose
- effective if insulin “resistance” absent

Question 3

Glypizide

Answer 3

Hypoglycemic compounds:
Sulfonylurea receptor activator (Inducers of Insulin Secretion)
Useful only in Type II (NIDD)
- inc insulin release - dec plasma glucose
- effective if insulin “resistance” absent

Question 4

Repaglinide

Answer 4

Hypoglycemic compounds:
K channel closers (inc Ca, Inducers of Insulin Secretion, for energy)
- inc insulin release - dec plasma glucose
- effective if insulin “resistance” absent

Question 5

Exenatide

Answer 5

Hypoglycemic compounds:
Protein activators of insulin secretion (Inducers of Insulin Secretion)
Useful only in Type II (NIDD)
- Mimics incretin – GI hormone
- inc insulin release - dec plasma glucose
- effective if insulin “resistance” absent

Question 6

Metformin

Answer 6

Hypoglycemic compounds:
Inhibitors of Glucose Absorption
- useful in type II, could use for type I
- dec Glucose absorption from GI
- dec Hepatic glucose production (from glycogen) & release (into blood)
- Effective regardless of insulin resistance

Question 7

Pioglitazone

Answer 7

Anti-Hyperglycemic compounds: Insulin Sensitizers

• useful in type II, could use for type I
• inc insulin affinity for its receptors
• inc body sensitivity to insulin
• inc insulin response
• Counteracts insulin “resistance”

Question 8

Rosiglitazone

Answer 8

Anti-Hyperglycemic compounds: Insulin Sensitizers

• useful in type II, could use for type I
• inc insulin affinity for its receptors
• inc body sensitivity to insulin
• inc insulin response
• Counteracts insulin “resistance”