Distribution studymate Flashcards
Volume of distribution = …………….. / concentration in plasma
Dose
The binding of a drug to plasma proteins ………. the effective concentration of drug in the plasma
Reduces
An example of a drug that can cross the placental barrier is:
Alcohol
Phocomelia is condition that can be caused by this teratogen.
Thalidomide
These drugs are extensively distributed into adipose tissue
General anaesthetics
Aspirin and warfarin bind extensively to
Plasma Proteins
The effectiveness of the blood brain barrier is due, in part, to the presence of
Tight Junctions
The distribution of the anticoagulant, heparin, is restricted to the ………….. compartment
Vascular
The blood brain barrier is composed of
Continuous capillaries
The antibiotic, tetracycline, tends to accumulate in
Bone
These form an additional layer of the blood brain barrier
Astrocytes
Plasma protein to which basic drugs such a lignocaine bind
Alpha-1 acid glycoprotein
