Absorption studymate Flashcards
Only the …………….. form of the drug can be absorbed.
Unionized (Unionized molecules are usually lipid soluble and can diffuse across cell membranes.)
Where would the Absorption of a weakly basic drug would be favoured?
Small intestine
An example of an acidic drug is
Aspirin
Opiates such as morphine are ………….. drugs
Basic
Rate of drug absorption is influenced by the ……………………… of the tissue around the site of administration
Vascularity (capillary network capable of delivering nutrients to the cells is formed within the tissue.)
Acidic drugs are less ionized when the pH is…
Low
Coefficient derived by measurement of the solubility of a drug in oil and water
Partition (when a solute is distributed between two phases in a separation process)
If a drug has a high partition coefficient, its lipid solubility is…
High
Basic drugs are less ionized when the pH is…
High
A weakly acidic drug is less ionized in the…
Stomach
Drug movement through membranes usually depends on the size of the…
Concentration gradient
Basic drugs, such as opiates, are less ionized when the pH of the surrounding medium is…
High
Active transport requires…
ATP
Acidic drugs are ……….. ionised when pH of the surrounding fluid is low.
Less
In some cases drugs may cross membranes by…
Active transport
