Distribution

Question 1

What causes drugs to be distributed quicket to tissues?

Answer 1

Better blood supply

Question 2

What does poor pefusion cause to drug absorption?

Answer 2

Slows it down

Question 3

What is a protein bound drug?

Answer 3

a drug molecule that is attached to large plasma proteins but are too large to diffuse across blood vessels to reach target cells/tissues
These drugs remain in the plasma ubtil the protein releases them, this occurs when the concentration of the free drug in the plasma falls

Question 4

What is a free drug?

Answer 4

Drugs that aren’t bound to plasma proteins that move by diffusion from the blood stream into tissues quickly as there is nothing preventing their movement

Question 5

What happens if you give 2 similar protein bound drugs at once?

Answer 5

Can lead to undesirable effects.
As they normally bind to the same plasma protein they compete which each other to bind to the same plasma protein.
The less highly bound drug will have fewer free proteins to attach to as the other drug has already attached to them. This increases the amount of the less highly bound drug that is free to leave the bloodstream, meaning this drug will move at a faster rate and at higher volumes
Or if both drugs attach to the proteins at the same rate the distribution rate and volume of each drug will be reduced meaning both drugs will provide a poorer affect than desired

Question 6

How is absorption from the GI tract affected?

Answer 6

There are several factors that may affect the absorption of frugs from the gut. Abnormal fut function can lead to reduced absorption and decreased bioavaiblity of the drug.
Vomiting will lead to expulsion of the drug before it reaches the SI for absorption. Diarhoea may cause the drug to not be present for a long enough time to be fully absorbed