dispensing lab Flashcards
a complete prescription contains
-patient demographics
-prescriber information
-drug name, strength, and dosage form
-directions for use and quantity
drug-drug interaction
-situations where one drug affects the pharmacokinetics or pharmacodynamics of another drug when both are administered together
-these interactions can alter the efficacy, or toxicity of the drugs involved potentially leading to adverse effects or therapeutic failures
pharmacokinetic interactions affect the:
Absorption
Distribution
Metabolism
Excretion
pharmacodynamic interactions
occurs when 2 drugs have the following interactions:
-Potentiation
-Antagonism
-Synergism
-Addition
addition interaction
1+1 =2
the combined effect of the 2 drugs is equal to the sum of their individual effect
Antagonistic interaction
1+1=0
one drug reduces or counteracts the effect of another drug
mostly used for toxicity/poisoning interactions
Synergism interaction
1+1=>2
the combined effect of 2 drugs are more than the sum of their individual effects
Potentiation interaction
1+0=2
one drug enhances the effect of another drug that has little or no effect on its own
addition interaction
benzodiazephines (diazepam) + 1st generation antihistamines
= increased sedation
losartan + amlodipine
= greater blood pressure lowering
medicol/advil + flanax /skelan
greater anti inflammatory effect
addition interaction side effects
GI bleeding and hepatotoxicity
antagonistic interaction
heparin + protamine sulfate
= avoid severe GI bleeding
antagonistic interaction
diazepam + flumazenil
treat benzodiazepine overdose
antagonistic interaction
naloxone/naltrexone + morphine, codeine, and heroin
= treat opioid addiction / toxicity
synergistic interaction
sulfamethoxazole + trimehoprim
= increased anti bacterial effects
synergistic interaction
pyrimethamine + sulfadoxine
= increased antimalarial effect
potentiation interaction
levodopa + carbidopa
= carbidopa prevents conversion of levodopa to dopamine outside the brain inhancing its efficacy
potentiation interactions
amoxicillin + clavulanic acid
= increased effectivity and half-life
potentiation interaction
ampicillin + sulbactam
= increased effectivity and half-life
potentiation interaction
piperacillin + tazobactam
= increase effectivity and half-life
checking availability of medicine
-physical inventory checking
-inventory management system (POS)
-supplier database
-government agencies (FDA, DOH)