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bspharma2 > DDS quiz > Flashcards

DDS quiz Flashcards

1
Q

The following are susceptible to the hydrolytic processes, EXCEPT:

A

Alkaloids

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2
Q

A characteristic which present substances that can exist in more than one crystalline form

A

Polymorphism

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3
Q

Inversely proportional

A

Dissolution rate & Particle size

Particle size & Surface area

Solubility & Particle size

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4
Q

Directly proportional

A

Solubility & Drug absorption

Solubility & Dissolution rate

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5
Q

Requirements of a proper design & formulation of dosage form:

A

-Compatible with one another
-Consideration with the physical, chemical and biological characteristics
-Manufactured under appropriate measures of quality control
-Properly labeled to promote the correct use and store in appropriate conditions

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6
Q

Microbiologic stability

A

Resistance to microbial growth

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6
Q

Physical stability

A

Unaltered appearance, palatability, uniformity and dissolution

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7
Q

Toxicologic stability

A

No significant increase in toxicity

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8
Q

Therapeutic stability

A

No change in therapeutic effect

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8
Q

A formulation that best meets the goals of the product

A

Master formula

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9
Q

Oxidation can be destructive to the following compounds, EXCEPT:

A

Esters

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10
Q

It is defined as the maximum concentration of a substance that can be completely dissolved in a given solvent at a certain temperature and pressure level

A

Drug solubility

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11
Q

Granules

A

Less likely to cake or harden upon standing
Easily wetted by liquid
More stable to atmospheric humidity

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11
Q

Dosage Form Design is crucial in pharmaceutics for several reasons, check the item/s that corresponds for its importance: (5 answers)

A

It can protect the active pharmaceutical ingredient from degradation and ensure that the drug remains effective
It can tailor the intended route of drug delivery and ensure the drug is administered appropriately
It encourage patience compliance in taking medications
It will ensures patients receive the correct and consistent amount of medication
It cab mask the bitter or unpleasant taste of drugs and improve palatability

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12
Q

Components of Soft gelatin Capsule (Pearls), EXCEPT:

A

Titanium dioxide

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12
Q

Powders

A

Relatively dry
Preferred for eutectic mixture

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13
Q

What to do when the powders contain volatile components

A

Wrapped in glassine paper and sealed in heat-sealed plastic bag

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13
Q

Hard Gelatin Capsule

A

Punch method
Contains 13- 16% water
Rolling method

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14
Q

Soft Gelatin Capsule

A

Plate process
Encapsulate and hermetically seal liquids and suspensions
Rotary die process

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15
Q

These are substances that tends to liquefy when in close and prolonged contact with one another

A

Eutectic substances

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16
Q

Dispensed in bulked quantities; dispensed in bulk containers: perforated or sifter can, aerosol container, wide mouthed glass

A

Bulk powders

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17
Q

Animal & Vegetable drugs- pass thru sieve no. 40- with fineness of nmt 40% thru no. 80 sieve:

A

Moderately coarse

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18
Q

This type of mortar pestle is not used in reactive substance:

A

Metal

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19
Q

Innovations of capsule shell designs wherein the rim is tapered, upper capsule part extends (rounded edge of lower surface is visible) while the opening is difficult and the lower surface has less gripping to pull 2 halves apart

A

Coni-snap supro

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20
Q

Powders are Intimate mixtures of dry, finely divided drugs and/or chemicals that maybe intended for internal or external use

A

TRUE

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21
Q

What to do when the powders contain hygroscopic and deliquescent materials?

A

Double wrapped in waxed paper

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22
Q

Wet Granulation method

A

Fluid bed processing
Basic Wet method

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23
Q

Dry Granulation method

A

Slugging method
Fusion method

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24
Q

These are substances that can absorb or adsorb water from its surroundings

A

Hygroscopic substances

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25
Q

Gelatin A is obtained from basic hydrolysis while Gelatin B is obtained from acid hydrolysis of collagen from skin, tissues and bones of animals

A

FALSE

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25
Q

Chemical powder- pass thru sieve no. 80- with no limit to greater fineness

A

Fine

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25
Q

Dispensed in: chartulae (folded paper), metal foil, small heat-sealed or resealable plastic bags

A

Divided powders

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26
Q

Mottling

A

Unequal distribution on a tablet with light or dark areas standing out

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26
Q

Picking

A

Removal of the tablet’s surface by punch

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26
Q

Dry Granulation tablet

A

Roller compaction
Slugging

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26
Q

Lamination

A

Separation of a tablet into 2 or more distinct layers

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26
Q

Capping

A

Partial or incomplete separation of the top or bottom crowns of a tablet from the main body of the tablet

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26
Q

Sticking

A

Adhesion of the tablet material to a die wall

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27
Q

Wet Granulation tablet

A

Fluid bed granulator
Microwave vacuum process

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28
Q

Direct compression

A

Without granulation process

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29
Q

Compressed tablet with colored or uncolored sugar layer, process includes seal coating (waterproofing), sub-coating, syrup coating (for smoothing and coloring) polishing & printing

A

Sugarcoated tablets

30
Q

Coated with a thin layer of a polymer, forming skin like film over the tablet

A

Film coated tablets

31
Q

Anhydrous & insoluble/ immiscible with water (difficult to wash off) and imparts emollient effect

A

Hydrocarbon bases

32
Q

Useful as pharmaceutical adjunct in incorporating small volumes of aqueous solution into hydrocarbon base

A

Absorption bases

33
Q

A dosage form used for insertion into the body orifices

A

Suppositories

34
Q

Absorption base

A

Lanolin, USP
Hydrophilic petrolatum

35
Q

Water-removable base

A

Hydrophilic ointment, USP

36
Q

Water-soluble base

A

Polyethylene glycol ointment, NF

37
Q

Oleaginous base

A

Yellow ointment, USP
White ointment, USP
Petrolatum, USP
White petrolatum, USP

38
Q

OINTMENTS are semi-solid dosage forms intended for external application to MOIST skin

A

FALSE

39
Q

Incorporation of solids in ointments wherein a small portion of the powder is mixed with a portion of the base until uniform

A

Geometric dilution

40
Q

Incorporation of solids in ointments wherein it is prepared by rubbing and working the components together on the hard surface until the product is smooth and uniform

A

Spatulation

41
Q

Common lubricant used in molding the suppository

A

Mineral oil
Almond oil
Sunflower oil
2 from the choices

42
Q

Topical applications are not required to be sterile with the exception of ophthalmic preparations

A

TRUE

42
Q

Do not contain oleaginous components

A

Water soluble bases

43
Q

Vaginal suppositories

A

Conical or Oviform in shape
Pessaries

44
Q

Urethral suppositories

A

Bougies
Pencil shape

45
Q

Rectal suppositories

A

Cylindrical & Bullet shape

46
Q

Selection of appropriate base for semi-solid dosage forms requires the following:

A

Effect if any of the drug on the consistency
Stability of the drug in the ointment base
Desirability of topical or percutaneous drug absorption
Characteristics of the surface to which it is applied

47
Q

Suppositories can be prepared by:

A

Compression in tablet press
Cold compression
Hand molding, rolling and shaping
Molding from fusion

48
Q

Semisolid preparation must be stored in well-closed containers to protect against contamination and stored in a cool place to protect against product separation in heat

A

TRUE

49
Q

Which is NOT a characteristic/s of the Cocoa butter

A

Melts between 25- 30°C

50
Q

Which is NOT TRUE about stratum corneum?

A

Behaves as a semi-permeable membrane and drug molecules can penetrate by active diffusion

51
Q

Oil-in-water emulsions resembling creams and may easily be washed from skin

A

Water removable bases

52
Q

Glycerogelatins contains the following, EXCEPT:

A

50% glycerin

53
Q

Semisolid system consisting of dispersion of small or large molecules in an aqueous liquid vehicle rendered jellylike by the addition of a gelling agent

A

Gels

54
Q

Lotions are usually lightweight and non-greasy. It has a high viscosity due to lower water content

A

FALSE

55
Q

Semisolid preparations containing one or more medicinal agents dissolved or dispersed in either a water-in-oil (W/O) emulsion or an oil-in-water (O/W) emulsion or in another type of water-washable base

A

Creams

56
Q

Pharmacist should be certain that upon dispensing, the patient understands the proper method of administration, frequency and duration of use, special warnings, therapeutic goals and anticipated outcomes, signs of adverse response, allergic sensitivity reaction or treatment failure, and reasons to discontinue treatment and seek further professional guidance

A

TRUE

57
Q

Glycerogelatins are applied to the skin for a short term. They are melted before application, cooled to slightly above body temperature, and applied to the affected area with a fine brush.

A

FALSE

57
Q

Preparation of Pastes:

A

Trituration method
Fusion method
Levigation method

58
Q

For removal of corns

A

Salicylic acid plaster

58
Q

For skin irritation/ rash

A

Zinc Oxide paste

59
Q

For varicose ulcers

A

Zinc gelatin bandage

60
Q

Preparation of Lotions:

A

Trituration
Chemical interaction

61
Q

Creams are generally described as either non-washable or washable, reflecting that an emulsion with an aqueous external continuous phase (O/W) is more easily removed than one with a non-aqueous external phase (W/O) emulsion

A

TRUE

62
Q

W/O

A

Emollient cream
Cold cream

62
Q

O/W

A

Shaving cream
Foundation cream

63
Q

Solid or semisolid adhesive masses spread on a backing of paper, fabric or moleskin, or plastic

A

Plasters

64
Q

acidifying agent

A

used in liquid preparations to provide acidic medium for product stability

citric
acetic
fumaric
hydrochloric
nitric

64
Q

alkalinizing agent

A

used in liquid preparations to provide alkaline medium for product stability

ammonia solution
ammonium carbonate
diethanolamine
monoethanolamine
potassium hydroxide
sodium borate, carbonate, hydroxide
trolamine

65
Q

adsorbent

A

an agent capable of holding other molecules onto its surface by physical or chemical (chemisorption) means

powdered cellulose
activated charcoal

66
Q

antioxidant

A

used to prevent deterioration by oxidation

ascorbic acid
ascorbyl palmitate
butylated hydroxyanisole, hydroxytoluene
sodium ascorbate, bisulfite, formaldehyde,
sulfoxylate

66
Q

aerosol propellant

A

agent responsible for developing the pressure within an aerosol container

carbon dioxide
dichlorodifluoromethane
dichlorotetrafluoroethane
trichloromonofluoromethane

67
Q

air displacement

A

agent employed to displace air in a hermitically sealed container

nitrogen
carbon dioxide

68
Q

chelating agent

A

forms stable water soluble complexes

edetic acid
edetate disodium

69
Q

emulsifying agent

A

promote and maintain dispersion

acacia
cetomacrogol
cetyl alcohol
glyceryl monostearate
sorbitan monooleate
polyoxuthylene 50 stearate

70
Q

encapsulating agent

A

gelatin

71
Q

humectant

A

prevent drying of preparations

glycerin
propylene glycol
sorbitol

72
Q

levigating agent

A

reduce the particle size by grinding

mineral oil
glycerin
propylene glycol

73
Q

ointment base

A

semisolid vehicle for medicated ointmnents

lanolin
hydrophilic ointment
polyethylene glycol
petrolatum
hydrophilic petrolatum
white ointment
yellow ointment
rose water ointment

74
Q

plasticizer

A

film coating solutions

diethyl phthalate
glycerin

75
Q

solvents

A

dissolve another substance

alcohol
corn oil
cottonseed oil
glycerin
isopropyl alcohol
mineral oil
oleic acid
peanut oil
purified water
water for injection
sterile water for injection, irrigation

76
Q

stiffening agent

A

increase thickness or hardness

cetyl alcohol
cetyl esters wax
microcrystalline wax
paraffin
stearyl alcohol
white wax,
yellow wax

77
Q

suppository bases

A

cocoa butter
polyethyelene glycols
PEG 3350

78
Q

surfactant
surface active agents

A

absorbs to surface to reduce surface or interfacial tension
wetting agents, detergents, emulsifying agents

benzalkonium chloride
nonaxynol 10
octaxynol 9
polysorbate 80
sodium lauryl sulfate
sorbitan monopalmitate

79
Q

sweetening agents

A

impart sweetness to a preparation

aspartame
dextrose
glycerin
mannitol
saccharin sodium
sorbitol
sucrose

80
Q

tablet antiadherents

A

prevent tablet ingredients from sticking to punches and dies

magnesium stearate

81
Q

tablet binders

A

cause adhesion of powder particles

acacia
alginic acid
ethylcellulose
gelatin
liquid glucose
methylcellulose
povidone
pregelatinized starch
compressible sugar

82
Q

sugar coating

A

liquid glucose
sucrose

83
Q

film coating

A

hydroxyethyl cellulose
hydroxypropyl celluloseen

84
Q

enteric coating

A

cellulose acetate
shellac

bspharma2 (18 decks)

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