DDS quiz Flashcards
The following are susceptible to the hydrolytic processes, EXCEPT:
Alkaloids
A characteristic which present substances that can exist in more than one crystalline form
Polymorphism
Inversely proportional
Dissolution rate & Particle size
Particle size & Surface area
Solubility & Particle size
Directly proportional
Solubility & Drug absorption
Solubility & Dissolution rate
Requirements of a proper design & formulation of dosage form:
-Compatible with one another
-Consideration with the physical, chemical and biological characteristics
-Manufactured under appropriate measures of quality control
-Properly labeled to promote the correct use and store in appropriate conditions
Microbiologic stability
Resistance to microbial growth
Physical stability
Unaltered appearance, palatability, uniformity and dissolution
Toxicologic stability
No significant increase in toxicity
Therapeutic stability
No change in therapeutic effect
A formulation that best meets the goals of the product
Master formula
Oxidation can be destructive to the following compounds, EXCEPT:
Esters
It is defined as the maximum concentration of a substance that can be completely dissolved in a given solvent at a certain temperature and pressure level
Drug solubility
Granules
Less likely to cake or harden upon standing
Easily wetted by liquid
More stable to atmospheric humidity
Dosage Form Design is crucial in pharmaceutics for several reasons, check the item/s that corresponds for its importance: (5 answers)
It can protect the active pharmaceutical ingredient from degradation and ensure that the drug remains effective
It can tailor the intended route of drug delivery and ensure the drug is administered appropriately
It encourage patience compliance in taking medications
It will ensures patients receive the correct and consistent amount of medication
It cab mask the bitter or unpleasant taste of drugs and improve palatability
Components of Soft gelatin Capsule (Pearls), EXCEPT:
Titanium dioxide
Powders
Relatively dry
Preferred for eutectic mixture
What to do when the powders contain volatile components
Wrapped in glassine paper and sealed in heat-sealed plastic bag
Hard Gelatin Capsule
Punch method
Contains 13- 16% water
Rolling method
Soft Gelatin Capsule
Plate process
Encapsulate and hermetically seal liquids and suspensions
Rotary die process
These are substances that tends to liquefy when in close and prolonged contact with one another
Eutectic substances
Dispensed in bulked quantities; dispensed in bulk containers: perforated or sifter can, aerosol container, wide mouthed glass
Bulk powders
Animal & Vegetable drugs- pass thru sieve no. 40- with fineness of nmt 40% thru no. 80 sieve:
Moderately coarse
This type of mortar pestle is not used in reactive substance:
Metal
Innovations of capsule shell designs wherein the rim is tapered, upper capsule part extends (rounded edge of lower surface is visible) while the opening is difficult and the lower surface has less gripping to pull 2 halves apart
Coni-snap supro
Powders are Intimate mixtures of dry, finely divided drugs and/or chemicals that maybe intended for internal or external use
TRUE
What to do when the powders contain hygroscopic and deliquescent materials?
Double wrapped in waxed paper
Wet Granulation method
Fluid bed processing
Basic Wet method
Dry Granulation method
Slugging method
Fusion method
These are substances that can absorb or adsorb water from its surroundings
Hygroscopic substances
Gelatin A is obtained from basic hydrolysis while Gelatin B is obtained from acid hydrolysis of collagen from skin, tissues and bones of animals
FALSE
Chemical powder- pass thru sieve no. 80- with no limit to greater fineness
Fine
Dispensed in: chartulae (folded paper), metal foil, small heat-sealed or resealable plastic bags
Divided powders
Mottling
Unequal distribution on a tablet with light or dark areas standing out
Picking
Removal of the tablet’s surface by punch
Dry Granulation tablet
Roller compaction
Slugging
Lamination
Separation of a tablet into 2 or more distinct layers
Capping
Partial or incomplete separation of the top or bottom crowns of a tablet from the main body of the tablet
Sticking
Adhesion of the tablet material to a die wall
Wet Granulation tablet
Fluid bed granulator
Microwave vacuum process
Direct compression
Without granulation process