Diseases of the Cardiovascular and Lymphatic System Flashcards
Chapter 23
What is Septicemia?
Presence of pathogens/toxins in blood causing acute illness
What is Sepsis?
Systemic inflammatory response syndrome (SIRS)
What is Lymphangitis?
Inflamed lymph vessels
What is Severe Sepsis?
Decreased blood pressure + dysfunction of at least one organ
What is Septic Shock?
Sepsis + uncontrollable decreased blood pressure
What are the Bacterial Diseases of the Cardiovascular + Lymphatic System? (4)
- Septicemia
- Plague
- Lyme Disease
- Rocky Mountain Spotted Fever
What are the Viral Diseases of the Cardiovascular + Lymphatic System? (2)
- Infection Mononucleosis
- Ebola Hemorrhagic Fever
What are the Protozoal Diseases of the Cardiovascular + Lymphatic System? (1)
- Malaria
Describe Septicemia:
- uncontrolled replication of bacteria in blood
Describe Sepsis (2):
- systemic inflammatory response syndrome (SIRS): release of inflammatory mediators in the bloodstream
- 1/3 nosocomial infections
How fast are nosocomial infections caught?
Within 24 hours of surgery
What is the mortality rate for nosocomial infections post surgery?
50-70% in USA
How do microbes enter the bloodstream? (2)
- wounds
- hospital procedures
Describe bacteremia:
Transient presence of bacteria in blood
Describe Lymphangitis (3):
- inflammation of lymph nodes
- sign of septicemia
- red streaks under skin
How does a gram (-) microbe cause septicemia?
Due to endotoxin release
What gram (-) microbes cause septicemia? (6)
- E. coli
- Pseudomonas aeruginosa
- Enterobacter aeroginus
- Klebsiella
- Proteus
- Serratia
How does a gram (+) bacteria cause septicemia? (2)
- due to exotoxins (toxic shock syndrome)
- more common
What gram (+) microbes cause septicemia? (3)
- staphylococcus
- streptococcus
- enterococcus
What 2 things accompany lymphangitis?
- septicemia
- septic shock
What other names are there for the plague? (2)
- black death
- bubonic plague
Was the bubonic plague caused by a bacteria or virus?
Bacteria
What bacteria caused the plague?
Yersinia pestis
Describe Yersinia pestis (3):
- caused the plague
- gram (-)
- rod
Which animals carry Yersinia pestis? (4)
- infected rats
- prairie dogs
- chipmunks
- squirrels
How was the plague transmitted?
From rat to rat through rat fleas
What are the virulence factors of Yersinia pestis? (4)
- capsules
- coagulase
- endotoxin
- surface antigens (2)
What do the surface antigens of Yersinia pestis do?
Resist Phagocytosis
(T/F) Yersinia pestis can replicate within a phagocyte.
True
Where does Yersinia pestis multiply in the body? (2)
- lymph
- blood
What kind of disease is the plague?
Zoonotic
How is the plague spread? (3)
- flea
- minor skin abrasions
- handling animals (rats)
Describe the bubonic plague (2):
- buboes
- high mortality rate
What are Buboes?
Swollen lymph nodes of groin & armpit
What is the mortality rate of the bubonic plague?
50-75%
What is the Septicemic Plague?
Microbe leaves lymphatics and enters the blood
What does the Septicemic Plague cause? (4)
- hemorrhage
- necrosis
- meningitis
- pneumonia
What is the Pneumonic Plague?
Microbe enters the lungs via inhalation
How fatal is the Pneumonic Plague?
Within a few days
How is the plague treated? (2)
- streptomycin
- tetracycline