Digestive System Flashcards

1
Q

What are the accessory organs of the digestive system?

A

Salivary glands, liver, gallbladder, pancreas

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2
Q

What is the alimentary canal composed of?

A

Mouth, pharynx, oesophagus, stomach, small intestine, large intestine, rectum, anus

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3
Q

What are the four layers of the gut?

A

Mucosa (innermost)
Submucosa
External muscle layers (muscularis externae)
Serosa

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4
Q

What does the mucosa consist of?

A

Epithelium, lamina propria and musculais mucosae

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5
Q

What is the submucosa of the gut wall?

A

A layer of connective tissue bearing glands, arteries, veins and nerves

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6
Q

What are the two layers of the external muscle of gut wall?

A

Outer longitudinal layer (cigar-shaped nuclei) and inner circular layer (central nuclei)

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7
Q

What does the muscularis externa create?

A

Peristaltic waves to move luminal contents along the gut

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8
Q

What does the serosa of the gut wall consist of?

A

Mesothelium and connective tissue

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9
Q

What are the major functions of the GI tract?

A

Mechanically disrupt food, temporarily store food chemically digest food, kill pathogens in food, move food along tract, absorb nutrients from resultant solution and eliminate residual waste material

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10
Q

What is digestion?

A

Conversion of what we eat by physical and chemical disruption into a solution that is relatively sterile, neutral in pH and isotonic from which we can absorb our nutrients.

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11
Q

What does saliva do?

A

It starts digestion as it contains amylase and lipase, is bacteriostatic as it contains immunoglobulin A antibody, protects teeth and assists swallowing.

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12
Q

How does physical digestion occur in the mouth?

A

By action of teeth, tongue and muscles of chewing

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13
Q

How does chemical digestion occur in the mouth?

A

By action of salivary amylase and lipase

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14
Q

What does the mouth form that enters the oesophagus?

A

A bolus

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15
Q

How does control differ between the upper and lower ends of the oesophagus?

A

Upper end - voluntary control (some striated skeletal muscle)

Lower end - involuntary control (solely smooth muscle)

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16
Q

How long does it take for the bolus to be transported to the stomach?

A

8-9 seconds

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17
Q

What are the layers of the oesophagus?

A

Mucosa (epithelium, lamina propria and muscularis mucosae) and submucosa

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18
Q

How is the oesophagus innervated?

A

Myentric plexus and submucosal plexus

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19
Q

How does physical digestion occur in the stomach?

A

Churning (3 muscle layers and mucosal rugae)

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20
Q

How does chemical digestion occur in the stomach?

A

By hydrochloric acid and enzymes eg pepsin

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21
Q

What is receptive relaxation of the stomach?

A

Wall relaxes so pressure doesn’t rise

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22
Q

How does the stomach protect its epithelium?

A

Secretes mucus

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23
Q

What is chyme?

A

Chewed up, partially digested stomach contents

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24
Q

The combined action of acid, enzymes and agitation of the stomach produces what?

A
Hypertonic chyme
(hypertonic = draw in fluid)
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25
Q

What does gastric mucosa secrete?

A

Acid, digestive enzymes and gastrin

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26
Q

How many layers of smooth muscle in the mucularis externa of the stomach?

A

3 - oblique, circular and longitudinal

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27
Q

What are rugae?

A

Folds of gastric mucosa forming longitudinal ridges in empty stomach

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28
Q

Which type of epithelium in the stomach?

A

Simple columnar epithelia

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29
Q

What can damage mucous cells in the stomach?

A

Alcohol and aspirin

30
Q

Which ions do the secreted mucous of the stomach contain?

A

Bicarbonate ions which neutralise the effect of H+ ions and thereby protect the stomach lining

31
Q

Which cells do gastric glands consist of?

A

Mucus secreting cells, parietal cells, chief cells, enteroendocrine cells

32
Q

What is the gastric pit of the gastric gland lined by?

A

Mucus secreting cells

33
Q

What is the isthmus in a gastric gland?

A

Region in which stem cells divide to populate the gland by upward or downward migration

34
Q

What do parietal cells in a gastric gland secrete?

A

H+ ions into the lumen and bicarbonate ions into nearby capillaries which move it to surface mucous cells

35
Q

What do chief cells in a gastric gland secrete?

A

Pepsinogens which are converted to pepsins

36
Q

What do enteroendocine cells in a gastric gland secrete?

A

Gastrin - the wider gastric muscosa responds to this hormone by secreting acid

37
Q

What is the duodenum?

A

20-25cm long, C shaped, proximal portion of small intestine that curves around head of pancreas

38
Q

What is contained in the walls of the duodenum?

A

Brunner’s glands which secrete bicabonate-rich mucus to neutralise acidic chyme

39
Q

Which two organs connect with the duodenum?

A

Liver and pancreas

40
Q

What does bile contain?

A

Water, alkali and bile salts to emulsify fat

41
Q

What does the small intestine consist of?

A

Duodenum, Jejunum, Ileum

42
Q

What does the duodenum absorb?

A

Iron

43
Q

What does the jejunum absorb?

A

Most of sugars, amino acids and fatty acids

44
Q

What does the ileum absorb?

A

Vitamin B12, bile acids and remaining nutrients

45
Q

By the terminal ileum, all of the nutrients are absorbed but what is still to be absorbed?

A

Water

46
Q

What does the large intestine consist of?

A

Caecum, ascending colon, transverse colon, descending colon, sigmoid colon

47
Q

Approximately how long and wide is the large intestine?

A

1.2m long and 6-9cm wide

48
Q

Which type of epithelia line the crypts of Lieberkuhn in the mucosa of the colon?

A

Simple columnar epithelia

49
Q

What does the large intestine do?

A

Continues water recovery over a 20 hr transit

50
Q

Where do the contents of the large intestine await expulsion?

A

In colon, not rectum

51
Q

Where is most of the GI tract’s bacteria contained?

A

Colon

52
Q

Are most bacteria in the colon aerobic or anaerobic?

A

Anaerobic

53
Q

What are the bacteria of the colon involved in?

A

Synthesis of [vitamins K, B12, thiamine and riboflavine]

Breakdown of primary and [secondary bile acids]

Coversion of bilirubin to [non-pigmented metabolites]

*Things in square brackets are readily absorbed

54
Q

What is the total volume of fluid produced by GI tract per day, without including fluid we drink?

A

14L

55
Q

How much faeces produced in a day from 1kg of food?

A

0.15kg. So 1kg food to 0.15kg of faeces via 14L fluid

56
Q

What does histamine do involving the stomach?

A

Controls production of acid in stomach

57
Q

What do vasoactive substances do?

A

Affect blood flow in gut

58
Q

What hormones is the gut controlled by?

A

Hormones it makes itself rather than hormones made elsewhere

59
Q

What does secretin do?

A

Promotes bicarbonate secretion from duct cells of panceas, promotes bile production by the liver and inhibits secretion of acid by parietal cells of the stomach.

60
Q

Where is cholecystokinin synthesised?

A

Enteroendocrine cells of the duodenum

61
Q

What does cholecystokinin promote?

A

Release of digestive enzymes from the pancreas and release of bile from the gall bladder as it stimulates it to contract

62
Q

Is cholecystokinin a hunger suppressant or stimulant?

A

Hunger suppressant

63
Q

What is gastrin released by?

A

G cells of pyloric antrum of stomach, pancreas, duodenum

64
Q

What does gastrin promote?

A

Production of gastric acid by parietal cells of the stomach

65
Q

What are the overall roles of the gut?

A

Secretion, movement and absorption

66
Q

What are the three salivary glands?

A

Sublingual gland, parotid gland and submandibular gland

67
Q

What stops us from inhaling what we are trying to swallow?

A

The epiglottis, flap of elastic cartilage attached to the larynx entrance, is open during inhalation and closes while swallowing to force food down the oesophagus

68
Q

Why is it more of a challenge to swallow fluids than solids?

A

More difficult to form a bolus as it needs more control and muscular contraction as well as more guidance into oesophagus

69
Q

Why doesn’t the stomach digest itself?

A

Epithelial cells lining the stomach secrete mucus which provides a physical barrier as well as containing bicarbonate which neutralises the acid. Also, proton pumps are only active in the presence of food and there are inactive enzyme precursors.

70
Q

What are the roles of bile?

A

Emulsify fats - increases surface area for enzymes to break them down

Facilitates fat absorption in the small intestine

Contains bile salts - deriveritive of cholesterol

Many waste products eg bilirubin are eliminated from the body by secretion into bile

Neutralises acid