Digestive Anatomy and Processes Pt 2 Flashcards
The stomach
- a j shaped sac: temporary storage tank (2-6 hours) and site of demolition
- starts chemical digestion - the breakdown of proteins
chyme
“juice”, liquified slurry of food
Stomach volumes
empty: 1/4 cup
full: 1 gallon
rugae
mucosal folds seen in an empty stomach
Muscularis
has an added internal, oblique layer to allow increased mixing and churning - more intense mechanical breakdown
Mucosa
contains simple columnar epithelium made entirely of mucous cells - produces a cloudy, protective double layer of alkaline mucous
Gastric Glands
the glands of the fundus and body are substantially larger and produce the majority of the stomach’s secretions
Mucus neck cells
produce thin, soluble mucus
parietal cells
produce HCI and secrete intrinsic factor (required to absorb B12)
chief cells
secrete pepsinogen and lipases
pepsinogen
inactive pepsin
enteroendocrine cells
secrete chemical messengers into the lamina propria as well as gastrin
Gastric juice
a corrosive acid with the ability to digest the stomach itself
Mucosal Barrier
produced to protect the stomach
- a thick coating of bicarbonate-rich mucus
- tight junction between epithelial cells
- quick replacement of damaged mucosal cells by stem cells
gastritis
inflammation of the stamach in response to breaches of the mucosal Barrier
peptic/gastric ulcers
erosions of the stomach wall, cause gnawing, epigastric pain
- pain typically appears 1-3 hours after eating and resolves with eating again
- ulcers are linked to peritonitis and H, pylori - a type of acid resistant bacteria
propulsion
peristalsis
mechanical breakdown
churning
digestion
breakdown of proteins by HCI and pepsin (rennin in infants)
absorption
only lipid-soluble substances - alcohol and aspirin
secretion of intrinsic factor
essential for B12 absorption and maturation of RBCs
Digestive process in the stomach order
- propulsion
- mechanical breakdown
- digestion
- absorption
- secretion of intrinsic factor
How much gastric juice is secreted a day
> 3L
Neural Mechanisms of Regulation
- stimulation by the vagus nerve increases secretion
- stimulating by the sympathetic Nervous System decreases secretion
Hormonal Mechanism of regulation
- gastrin stimulates secretion of HCI by the stomach
- gastrin stimulates secretion of gastrin antagonists by the SI
Regulation of gastric secretion
control of HCI - secreting parietal cells is multifaceted - secretion is simultaneously by ACh, gastrin, histamine