Diazapem

Question 1

MOA of diazepam ?

Answer 1

Benzodiazepines
Bind to specific site on GABA receptor (different from GABA-binding site)
2 8 - suburt
Increase in frequency of opening of cit channels
Increase in GABA-mediated chloride current
Membrane hyperpolarization
CNS depression

Question 2

Uses of diazepam

Answer 2

AC
DÌ A (Z EP A M (Uses of BZDs: Mnemonic)
→ Muscle relaxant
→ Anxiolytic
> Preanaesthetic medication
→ Anticonvulsant
> Insomnia
> Diagnostic and minor operative procedure:
• Conscious sedation
> Alcohol withdrawal symptoms