dialysis Flashcards

1
Q

indications for starting emergency dialysis

A

hyperkalaemia // eGFR <7 // urea >40 // unresponsive met acidosis

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2
Q

what is eGFR renal failure

A

<15

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3
Q

symptoms renal failure

A

SOB, fatigue, itch, can’t eat, N+V, muscle cramp, anxiety + depression,

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4
Q

frequency of haemodialysis

A

3/wk for 3-5 hours each

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5
Q

what is removed and replaced in haemodialysis

A

out = urea, K, Na // in = water, HCO3, glucose

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6
Q

dietary restrictions dialysis

A

1L fluid // low salt // low K // low phosphate

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7
Q

gold standard access for dialysis

A

AV fistula

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8
Q

how long do fistulas take to develop

A

6-8 weeks

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9
Q

sites for AV fistula

A

Radio-cephalic / Brachiocephalic / Brachio-basilic

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10
Q

SE AV fistulas (4)

A

infection, thrombosis, stenosis, steal syndrome

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11
Q

what is a tunnelled venous catheter

A

catheter –> large vein eg internal jugular (not preferred anymore)

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12
Q

what drives waste exchange in PD

A

dextrose in dialysis solution

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13
Q

what is Continuous ambulatory peritoneal dialysis (CAPD)

A

exchange lasts 30-40 minutes then dialysis solution inserted into abdomen for 4-8 hours // patient can go about day with solution in abdomen // 4x2L per day

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14
Q

what is automated peritoneal dialysis (APD)

A

dialysis machine fills and drains abdomen whilst patient is sleeping // 3-5 exchanges over 8-10 hours

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15
Q

when is PD preferred

A

when patients do not want to enter hospital 3x a week

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16
Q

commonest complication PD

A

peritonitis

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17
Q

orgnaism peritonitis

A

1 = staph epi // 2 = staph A // sometimes gram-ives from gut

18
Q

mx peritonitis

A

vanco + ceftazidime into PD // OR vanco into PD + cipro oral

19
Q

what antigens are present on type O blood

20
Q

who can type O blood donate + recieve

A

donate to everyone // receive only

21
Q

who can type O blood donate + recieve

A

donate to everyone // receive only O

22
Q

who can type AB donate + recieve from

A

receive everyone only donate to AB

23
Q

what are the 4 most important HLA alleles + which are most important to match

A

DR most –> B –> A (–> C least)

24
Q

what happens if the body encounters and HLA allele not found within the body

A

sensitising event –> activate T cells –> auto-antibodies

25
what chromosome is HLA on
6
26
what is an allogrant transplant
non-identical same species eg non-related organ donor
27
what is isograft transplant
donation of identical organ eg identical twins
28
what is autograft transplant
from one tissue of a person eg skin graft
29
what is xenograft transplant
from another species eg porcine heart valve
30
post-op problems kidney transplant
acute tubular necrosis // thrombosis // urine leak // UTI
31
what causes hyper-acute rejection
antibodies to ABO or HLA (type II hypersensitivity)
32
symptoms of hyperacute rejection + mx
thrombosis of graft --> ischaemia of organ // takes minutes to hours // remove graft
33
what causes acute graft failure
HLA mediated (T cells) // CMV infection
34
symptoms acute graft failure
< 6months months // rising creatinine, pyuria, proteinuria
35
diagnosis CMV
PCR IgG
36
mx acute graft failure
steroids + immunosuppression
37
mx CMV
Prophylactic valganciclovir // IV ganciclovir
38
causes chronic graft failure
antibody + cell mediated --> fibrosis (over 6+ months)
39
exclusion criteria renal transplant
cancer + old ge
40
what initial immunosuppression is used in renal transplant
ciclosporin/ tacrolimus + monoclonal antibody
41
maintenance immunosuppression renal transplant
ciclosporin/ tacrolimus + MMF or sirlomus // + steroid in acute rejection