diabetes drugs

Question 1

lactic acidosis is a rare but worrisome side effect

Answer 1

metformin

Question 2

MC ADE is hypoglycemia

Answer 2

sulfonylureas

Question 3

recommended first line tx for most pts

Answer 3

metformin

Question 4

not safe in settings of hepatic dysfxn or CHF

Answer 4

TZDs

Question 5

Should not be used in pts w/ cirrhosis or IBD

Answer 5

alpha-glucosidase inhibitors

Question 6

Not associated w/ weight gain

Answer 6

metformin, DPP-4 inh, GLP-1 analogs

Question 7

Metabolized by liver; excellent choice in pts w/ renal dz

Answer 7

TZDs

Question 8

MOA: closes K channel on beta cells -> depolarization -> Ca influx -> insulin release

Answer 8

sulfonylureas

Question 9

MOA: inhibits alpha-glucosidase at intestinal brush border

Answer 9

alpha glucosidase inh

Question 10

MOA: agonist at PPAR gamma receptors -> improved target cell response to insulin

Answer 10

TZDs

Question 11

MOA: decreases hepatic gluconeogenesis

Answer 11

metformin

Question 12

Good for weight loss

Answer 12

GLP-1 agonists

Question 13

Avoid in hypoglycemia

Answer 13

sulfonylureas

Question 14

Best tx for anyone w/ organ failures (renal, liver, heart)

Answer 14

insulin