cancer drugs

Question 1

alkylates DNA, ADE: pulm fibrosis

Answer 1

Busulfan

Question 2

fragments DNA, ADE: pulm fibrosis

Answer 2

bleomycin

Question 3

Blocks purine synth, metabolized by xanthine oxidase

Answer 3

6-MP

Question 4

nitrogen mustard, alkylates DNA (electrophile that binds DNA)

Answer 4

nitrosoureas

Question 5

folic acid analog that inhibits dihydrofolate reductase

Answer 5

MTX

Question 6

intercalates DNA, produces O2 free radicals, cardotoxic

Answer 6

doxorubicin daunorubicin

Question 7

DNA alkylating agents used in brain cancer

Answer 7

nitrosoureas

Question 8

applied topically for AKs and basal cell cancers

Answer 8

5 FU

Question 9

tx for childhood tumors (ewing sarcoma, wilma tumor, rhabdomyosarcoma)

Answer 9

dactinomycin

Question 10

ADE: hemorrhagic cystitis

Answer 10

cyclophosphamide, ifosfomide

Question 11

crosslinks DNA, nephrotoxic and ototoxic

Answer 11

cysplatin

Question 12

prevents tubulin disassembly

Answer 12

paclitaxel

Question 13

inhibits ribonucleotide reductase

Answer 13

hyroxyurea

Question 14

inhibitor of the mutated tyrosine kinase produced by the philadelphia chromosome

Answer 14

imatinib

Question 15

monoclonal Ab against HER2

Answer 15

trastuzumab

Question 16

SERM that does not increase the risk of endometrial cancer

Answer 16

raloxifene