Diabetes Drugs

Question 1

What drug class are gliptins?

Answer 1

DPP4 Inhibitors

Question 2

Action of DPP4 inhibitors

Answer 2

Prevents degradation of GLP-1 (increases pancreatic insulin production)

Delays gastric emptying and decreases glucagon production

Question 3

name a glitazone

Answer 3

Pioglitazone

Question 4

When do you add another drug to diabetic treatment?

Answer 4

HBA1c >58

Question 5

Side effects of sulphonylureas?

Answer 5

HYPO

Weight gain

Question 6

Action of metformin?

Answer 6

increases insulin sensitivity
increases glucose uptake to tissues (decreases blood glucose) glycolysis
decreases glyconeogenesis

Question 7

Action of sulphonylurea

Answer 7

Inhibits K+ channel preventing K+ exocytosis and causing depolarisation of beta cells

Question 8

Side effect of metformin

Answer 8

Lactic acidosis (renal insufficiency)
GI upset

Question 9

Why is metformin often held on hospital admission?

Answer 9

Increased risk of lactic acidosis if Contrast imaging needed

Question 10

Examples of sulphonylureas

Answer 10

Glipizide (ending IDE)

Question 11

Side effects of DPP4 inhibitors?

Answer 11

UTI

Resp infection

Question 12

Examples of GLP1 agonists

Answer 12

Exanetide, liraglutinide

Question 13

Side effects of GLP1 agonists

Answer 13

Pancreatitis

Question 14

Criteria for diagnosis of diabetes

Answer 14

If the patient is symptomatic:
fasting glucose greater than or equal to 7.0 mmol/l
random glucose greater than or equal to 11.1 mmol/l (or after 75g oral glucose tolerance test)

If the patient is asymptomatic the above criteria apply but must be demonstrated on two separate occasions.

Question 15

Treatment for HNF1 MODY?

Answer 15

SU