Developmental defects - Funny Looking Things Flashcards
What causes orofaccial clefts?
Secondary to lack of or improper merging & fusion of developmental process. Environmental and genetic factors.
Lateral palatine process also known as
Secondary palate/hard palate
What happens if secondary palate doesnt zip up?
Bifid uvula
List the various cleft
Cleft lip, cleft palate, Lateral facial cleft, Oblique facial cleft
Median cleft of the upper lip & Median maxillary anterior alveolar cleft
Environmental factors that cause orofacial clefts.
Maternal alcohol & cigarettes, folic acid deficiency, corticosteroid use, Anticonvulsants,
What is a syndrome?
3 or more clinical problems that occur together more frequently than statistically they should occur.
Cleft lip and or palate is?
failure of medial nasal process (primary palate) & maxillary process to fuse
What percent do cleft lip and palate occur together?
45%
30% CP alone
25% CL alone
3 - 8% associated with syndromes.
Complete and incomplete cleft
Complete goes all the way up to the nares. Incomplete does not.
Cleft lip more common in?
Males
Asians higher occurrence and Blacks lower
Cleft palate is?
failure of the palatal shelves to come together and fuse.
Cleft plate is more common in?
Females
ranges from severe to mild
What is minimal cleft palate?
Bifid uvula also mild cleft palate.
Bifid uvula is has high frequency in which race?
Asian and Native American.
Less common in Blacks
Pierre Robin Syndrome
Cleft Palate + Mandibular Micrognathia + Glossoptosis + Airway obstruction
Problems with Pierre Robin Syndrome?
Feeding, speech and malocclusion.
Tx: Surgical repair
Commussural Lip pits
blind invaginations 1-4mm deep located at the commissures. Painless
Commussural Lip pits are common in?
Males . No Tx necessaryy
Paramedian Lip Pits
This are pits on the lip like deep fingernail prints
Van der Woude syndrome
Paramedian Lip pits + cleft lip & or palate
Double lip
Upper lip showing a redundant fold on mucosal side. Drops down & out when smiling.
Congenital & isolated or found with Ascher syndrome
Ascher syndrome
Double lip + Blespharochalasis (double eyelid) + Nontoxic thyroid enlargement
Fordyce granules
Ectopic sebaceous gland on oral mucosa. Yello or yellowish-white papules.
Most common location of fordyce granules
buccal mucosa & vermilion border of lip.
LESS COMMON on retromolar area & tonsillar pillar