Developmental Aspects Of The Lungs Flashcards

1
Q

Embryonic phase

A

3-18 weeks

Lung bud starts to develope from foregut

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2
Q

Psuedoglandular phase

A

5-17

Rapid branching of the Airways

Development of mucous and cillia cells in airways

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3
Q

Camalicular phase

A

16-26 weeks

Starts to develop alveoli and capillaries

Type 1 and 2 alveoli cells

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4
Q

Saccular phase

A

24-38

Alveoli sacs increase in size and produce more surfactant

Interstial space reduces

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5
Q

Alveolar phase

A

36 weeks-2/3 years

Better vasculature

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6
Q

What is Laryngomalacia

A

A floppy-ness of the airway

An abnormal collapse of the larynx

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7
Q

Clinical signs of laryngomalacia

A

Present with stridor

Worse when feeding or when uoser/excited

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8
Q

Treatment of laryngomalacia

A

Will normal improve in first year

Cause for concern if affects feeding, growth or causes apnoeas

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9
Q

What is tracheomalacia

A

A floppyness of the trachea

Typically genetic

May be caused by external pressures (vessels or tumors)

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10
Q

Clinical signs of tracheomalacia

A

Barking cough

Recurrent croup

Breathless on exertion

Stridor/wheeze

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11
Q

Treatmemt of Tracheomalacia

A

Typically no treatment, gets better with age

When child is unwell may require antibiotics and physio

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12
Q

What is a tracheo-oesphageal fistula

A

An abnormal connection between the trachea and the oesophagus

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13
Q

Clinical signs of tracheo-oesphageal fistula

A

Can be picked up antenatally but typically postnatally

Presentation-
Choking 
Colour change 
Cough from feeding 
Unable to pass NG tube
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14
Q

Treatment of tracheo-oesphageal fistula

A

Surgery

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15
Q

What is congenital pulmonary airway malformation (CPAM)

A

A general term for abnormal non-functional lung tissue

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16
Q

Clinial signs of CPAM

A

Spotted antenatally

17
Q

Treatment of CPAM

A

May resolve spontaneously in utero

No need for management if a symptomatic

May need surgery

Risk of malignant change

18
Q

What is congenital Diaphragmatic hernia

A

Where diaphragm doesn’t close properly

Typically on left

19
Q

Clinical signs of congenital diaphragmatic hernia

A

Typically spotted antenatally

If spotted late- xray

20
Q

Treatment for congenital diaphragmatic hernia

A

Surgery

21
Q

What is respiratory distress syndrome (RDS)

A

Surfactant deficiency