Development Of The Genital System Flashcards
How long is the gonad identical in male & female
Till the 7th week of development
Where do primordial germ cells migrate to in the 6th week
Genital ridges
What develops medial to the mesonephric ridge
Genital ridge
What is paramesonephric duct aka
Mullerian duct
What is the mesonephric duct aka
Wolffian duct
As primordial germ cells arrives what happens to form primitive sex cords
Epithelium invades the mesenchyme
What genes drive testes development
SRY and SOX9
During sex differentiation, what duct degenerates in a) males and b) females and give the substance responsible
a) paramesonephric duct degenerates - anti- mullerian hormone
b) mesonephric duct regresses - oestrogen
What genes drive female development
Absence of SRY
SOX9 is inhibited
WNT4 is crucial for ovarian development
Under the influence of testis determining factor, what do the primitive sex cords form
Develop and Form the testis cords
Which 2 cells are the testis cords composed of
Sertoli cells - develop from the surface epithelium if the gonad
Primordial germ cell
What does the mesenchyme in the gonadal ridge give rise to
Leydig cells which lie between the cords
When do leydig cells start producing testosterone
8th week
What happens to primitive sex cords in females
They regress
What does the surface epithelium give rise to in females and what do they do
Cortical cords
They invade the mesenchyme and split it into clusters of cells which surround each germ cell
What 2 things give rise to the primordial follicle
Germ cell and surrounding follicular cells
How do the testes descend into the pelvis
Through deep ring, inguinal canal and superficial ring
What happens to the canal between the processus vaginalis and peritoneal cavity around birth
It closes
During ovary descent to the pelvis, where does the round ligament run
In the inguinal canal to the labia majora
What does the paramesonephric duct open into
The abdominal cavity at its rostral end
What occurs at the caudal end of the Müllerian duct as they develop
Caudal ends meet in the midline and project into the urogenital sinus
Where does the mesonephric duct open into
Urogenital sinus
in males, the distal ends of the mesonephric duct opens into the urogenital sinus to form……
Ejaculatory ducts - prostate develops around it
What produces anti Müllerian hormone
Sertoli cells
