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DHS2🎐 > Development of teeth > Flashcards

Development of teeth Flashcards

1
Q

when and where does the primary epithelial band appear

A

appears at 5-6 weeks of development in future maxilla and mandible and its a horseshoe shaped band of thickened epithelium in the position of future dental arches

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2
Q

what is the dental lamina and how does it develop

A

dental lamina is derived from the primary epithelial brand and around 7 weeks the epithelial band divides into

1-vestibular lamina( buccally forms vestibule)
2- dental lamina ( lingually forms teeth)

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3
Q

what are the main stages of tooth development

A
  • bud stage
    -cap stage
  • bell stage
    -crown formation
  • dentinogenesis
    -amelogensis
  • root formation
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4
Q

stages of tooth eruption include

A
  • bud stage
    -cap stage
  • bell stage
  • crown stage
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5
Q

list the 3 process that overlap the stages of tooth development

A

-initiation: establish site of future teeth
- morphogenesis : determines shape of tooth
- histogenesis : differentiation of cells into specific types

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6
Q

where does tooth development occur

A

stomatodeum

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7
Q

what interactions are involved in tooth development

A

interactions between ectoderm and ectomesenchyme

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8
Q

what lines stomatodeum during tooth development

A

by thin epithelium derived from ectoderm

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9
Q

what is the significance of primary epithelial band in tooth development

A

its a superficial epithelial thickening in position of future dental arches and is crucial for initiation of tooth development

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10
Q

where do deciduous and permanent dentitions arise from

A

dental lamina

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11
Q

how does deciduous teeth develop

A

from initial development of dental lamina

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12
Q

when does the proliferation of epithelium for deciduous teeth occur

A

around 13 weeks in utero to initiate tooth formation

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13
Q

how do early tooth germs form in deciduous teeth

A

epithelium proliferates at 10 sites in each dental lamina forming early tooth germs

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14
Q

what initiates the formation of permanent incisors, canines, and premolars

A

results from further proliferation of dental lamina on lingual aspect of deciduous tooth germ

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15
Q

where does the proliferation of dental lamina occur

A

lingual aspect of deciduous tooth germ

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16
Q

what happens to the permanent tooth germ after its formed

A

it remains inactive for sometime after initial formation until the deciduous tooth is ready to be replaced

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17
Q

do permanent molar teeth have deciduous

A

no permanent teeth doesn’t have deciduous predecessors

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18
Q

how do permanent molar teeth develop

A

from the growth of dental lamina posteriorly so posterior extension

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19
Q

which layer initiates tooth development in the first 2 weeks of embryogenesis

A

epithelium from 1st branchial arch

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20
Q

how do neural crest cells and mandibular epithelium interact in tooth development

A

when the neural crest cells interact with mandibular epithelium they form tooth, bone, and cartilage

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21
Q

what happens when neural crest cells interact with limb epithelium instead of mandibular epithelium

A

they form only bone and cartilage

22
Q

after initial stages of tooth development which structure takes over the process

A

ectomesenchyme takes over

23
Q

which growth factor is involved in signaling gene expression in neural crest cells during tooth development

A

Fgf-8 growth factor from oral epithelium induces gene expression in neural crest cells

24
Q

what genes are induced by Fgf-8 and expressed in the ectomesenchyme of 1st arch

A

Lhx-6 and Lhx-7 are induced by Fgf-8 and expressed early in the ectomesenchyme cells of 1st arch

25
which gene defines the exact sites where tooth germ appear
Pax-9 gene controls the positioning of teeth
26
how is the shape of teeth controlled before and after day 11 of development
before day 11= epithelium " ectoderm" controls shape of teeth after day 11= ectomesenchyme cells determine shape using homeobox genes
27
what happens when molar epithelium is combined with incisor ectomesenchyme before and after day11
before day 11 = results in molar because the epithelium controls the shape of tooth after day 11= results in incisor because the ectomesenchyme controls shape of tooth
28
how many genes have been identified in the initiation of tooth development
90 genes
29
ectomesenchyme can induce what
can induce tooth formation with oral epithelium and even non oral like foot epithelium
30
At what stage and week do individual epithelial buds appear on the dental lamina, and what happens to ectomesenchyme cells during this time
At the *Bud Stage (~8 weeks in utero)*, individual epithelial buds (swellings) form on the deep surface of the dental lamina. Ectomesenchyme cells become closely packed around the epithelial bud.
31
Do epithelial cells change in shape or function during the bud stage
no, there is *little to no change* in the shape or function of epithelial cells during the bud stage
32
What characterizes the *Cap Stage (~11 weeks in utero)* of tooth development
the epithelial bud proliferates and invaginates, forming a *cap shape, and there is **more condensation* of ectomesenchyme cells.
33
How does morphogenesis occur in the enamel organ during the cap stage
Morphogenesis increases: the *central cells* of the enamel organ become *spherical, while the **peripheral cells* become *cuboidal*.
34
By what week does the late cap stage occur, and what happens to the enamel organ
by *~12 weeks in utero, the enamel organ cells differentiate into three layers: **Outer Enamel Epithelium (OEE), **Inner Enamel Epithelium (IEE), **Stellate Reticulum (SR)*.
35
Into what does the ectomesenchyme proliferate during the late cap stage
proliferates into the dental papilla (precursor to dentin and pulp) and dental follicle (sac) (precursor to cementum, periodontal ligament, and alveolar bone)
36
What are the three layers of the enamel organ during the late cap stage, and how do the cells differ in shape
- *Outer Enamel Epithelium (OEE)*: cuboidal cells. - *Inner Enamel Epithelium (IEE)*: columnar cells. - *Stellate Reticulum (SR)*: star-shaped cells connected by desmosomes with intercellular spaces
37
what does the enamel organ become in future
enamel
38
what does the dental papilla become in future
dentin and pulp
39
what does the dental follicle become in future
cementum pdl bone of tooth socket
40
what happens during bell stage of tooth development
tooth crown takes its final shape and enamel organ diff into 4 layers
41
list the 4 layers of the enamel organ in bell stage
inner enamel ep stratum intermedium stellate reticulum outer enamel ep
42
inner enamel ep function in bell stage
responsible for enamel formation made of columnar determines shape of crown
43
stratum intermedium function in bell stage
consists of 2-3 layers of flat cells that help in supporting enamel formation by assisting IEE
44
stellate reticulum function in bell stage
star shaped cells that secrete intracellular fluid to protect inner enamel ep and dental papilla
45
outer enamel function in bell stage
consist of cuboidal responsible for substance exchange with blood vessels in dental sac
46
what happens to dental lamina during bell stage
it breaks down separating tooth germ from oral ep and remnants may be present and called" epithelial pearls"
47
what is enamel niche
an artifact in histological sections caused by cutting through dental lamina
48
what is enamel knot
temporary structure seen in molar tooth development during cap stage and acts as reservoir of cells for the growing enamel organ and may influence crown formation
49
what is enamel cord
structure running from the enamel knot to outer enamel epithelium during early bell stage and help determine initial position of 1st cusp during crown pattern formation
50
What happens in the crown stage of tooth development
In the crown stage, dentine and enamel begin to form. The inner enamel epithelium cells differentiate into pre-ameloblasts, which induce the formation of odontoblasts from dental papilla. Dentine secretion triggers ameloblast differentiation, initiating enamel formation

DHS2🎐 (13 decks)

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