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DHS2🎐 > Development of teeth > Flashcards

Development of teeth Flashcards

1
Q

when and where does the primary epithelial band appear

A

appears at 5-6 weeks of development in future maxilla and mandible and its a horseshoe shaped band of thickened epithelium in the position of future dental arches

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2
Q

what is the dental lamina and how does it develop

A

dental lamina is derived from the primary epithelial brand and around 7 weeks the epithelial band divides into

1-vestibular lamina( buccally forms vestibule)
2- dental lamina ( lingually forms teeth)

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3
Q

what are the main stages of tooth development

A
  • bud stage
    -cap stage
  • bell stage
    -crown formation
  • dentinogenesis
    -amelogensis
  • root formation
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4
Q

stages of tooth eruption include

A
  • bud stage
    -cap stage
  • bell stage
  • crown stage
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5
Q

list the 3 process that overlap the stages of tooth development

A

-initiation: establish site of future teeth
- morphogenesis : determines shape of tooth
- histogenesis : differentiation of cells into specific types

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6
Q

where does tooth development occur

A

stomatodeum

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7
Q

what interactions are involved in tooth development

A

interactions between ectoderm and ectomesenchyme

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8
Q

what lines stomatodeum during tooth development

A

by thin epithelium derived from ectoderm

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9
Q

what is the significance of primary epithelial band in tooth development

A

its a superficial epithelial thickening in position of future dental arches and is crucial for initiation of tooth development

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10
Q

where do deciduous and permanent dentitions arise from

A

dental lamina

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11
Q

how does deciduous teeth develop

A

from initial development of dental lamina

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12
Q

when does the proliferation of epithelium for deciduous teeth occur

A

around 13 weeks in utero to initiate tooth formation

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13
Q

how do early tooth germs form in deciduous teeth

A

epithelium proliferates at 10 sites in each dental lamina forming early tooth germs

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14
Q

what initiates the formation of permanent incisors, canines, and premolars

A

results from further proliferation of dental lamina on lingual aspect of deciduous tooth germ

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15
Q

where does the proliferation of dental lamina occur

A

lingual aspect of deciduous tooth germ

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16
Q

what happens to the permanent tooth germ after its formed

A

it remains inactive for sometime after initial formation until the deciduous tooth is ready to be replaced

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17
Q

do permanent molar teeth have deciduous

A

no permanent teeth doesn’t have deciduous predecessors

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18
Q

how do permanent molar teeth develop

A

from the growth of dental lamina posteriorly so posterior extension

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19
Q

which layer initiates tooth development in the first 2 weeks of embryogenesis

A

epithelium from 1st branchial arch

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20
Q

how do neural crest cells and mandibular epithelium interact in tooth development

A

when the neural crest cells interact with mandibular epithelium they form tooth, bone, and cartilage

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21
Q

what happens when neural crest cells interact with limb epithelium instead of mandibular epithelium

A

they form only bone and cartilage

22
Q

after initial stages of tooth development which structure takes over the process

A

ectomesenchyme takes over

23
Q

which growth factor is involved in signaling gene expression in neural crest cells during tooth development

A

Fgf-8 growth factor from oral epithelium induces gene expression in neural crest cells

24
Q

what genes are induced by Fgf-8 and expressed in the ectomesenchyme of 1st arch

A

Lhx-6 and Lhx-7 are induced by Fgf-8 and expressed early in the ectomesenchyme cells of 1st arch

25
Q

which gene defines the exact sites where tooth germ appear

A

Pax-9 gene controls the positioning of teeth

26
Q

how is the shape of teeth controlled before and after day 11 of development

A

before day 11= epithelium β€œ ectoderm” controls shape of teeth
after day 11= ectomesenchyme cells determine shape using homeobox genes

27
Q

what happens when molar epithelium is combined with incisor ectomesenchyme before and after day11

A

before day 11 = results in molar because the epithelium controls the shape of tooth

after day 11= results in incisor because the ectomesenchyme controls shape of tooth

28
Q

how many genes have been identified in the initiation of tooth development

A

90 genes

29
Q

ectomesenchyme can induce what

A

can induce tooth formation with oral epithelium and even non oral like foot epithelium

30
Q

At what stage and week do individual epithelial buds appear on the dental lamina, and what happens to ectomesenchyme cells during this time

A

At the Bud Stage (~8 weeks in utero), individual epithelial buds (swellings) form on the deep surface of the dental lamina. Ectomesenchyme cells become closely packed around the epithelial bud.

31
Q

Do epithelial cells change in shape or function during the bud stage

A

no, there is little to no change in the shape or function of epithelial cells during the bud stage

32
Q

What characterizes the Cap Stage (~11 weeks in utero) of tooth development

A

the epithelial bud proliferates and invaginates, forming a cap shape, and there is **more condensation of ectomesenchyme cells.

33
Q

How does morphogenesis occur in the enamel organ during the cap stage

A

Morphogenesis increases: the central cells of the enamel organ become spherical, while the **peripheral cells become cuboidal.

34
Q

By what week does the late cap stage occur, and what happens to the enamel organ

A

by ~12 weeks in utero, the enamel organ cells differentiate into three layers: **Outer Enamel Epithelium (OEE), **Inner Enamel Epithelium (IEE), **Stellate Reticulum (SR).

35
Q

Into what does the ectomesenchyme proliferate during the late cap stage

A

proliferates into the dental papilla (precursor to dentin and pulp) and dental follicle (sac) (precursor to cementum, periodontal ligament, and alveolar bone)

36
Q

What are the three layers of the enamel organ during the late cap stage, and how do the cells differ in shape

A
  • Outer Enamel Epithelium (OEE): cuboidal cells.
    • Inner Enamel Epithelium (IEE): columnar cells.
    • Stellate Reticulum (SR): star-shaped cells connected by desmosomes with intercellular spaces
37
Q

what does the enamel organ become in future

A

enamel

38
Q

what does the dental papilla become in future

A

dentin and pulp

39
Q

what does the dental follicle become in future

A

cementum
pdl
bone of tooth socket

40
Q

what happens during bell stage of tooth development

A

tooth crown takes its final shape and enamel organ diff into 4 layers

41
Q

list the 4 layers of the enamel organ in bell stage

A

inner enamel ep
stratum intermedium
stellate reticulum
outer enamel ep

42
Q

inner enamel ep function in bell stage

A

responsible for enamel formation
made of columnar
determines shape of crown

43
Q

stratum intermedium function in bell stage

A

consists of 2-3 layers of flat cells that help in supporting enamel formation by assisting IEE

44
Q

stellate reticulum function in bell stage

A

star shaped cells that secrete intracellular fluid to protect inner enamel ep and dental papilla

45
Q

outer enamel function in bell stage

A

consist of cuboidal
responsible for substance exchange with blood vessels in dental sac

46
Q

what happens to dental lamina during bell stage

A

it breaks down separating tooth germ from oral ep and remnants may be present and called” epithelial pearls”

47
Q

what is enamel niche

A

an artifact in histological sections caused by cutting through dental lamina

48
Q

what is enamel knot

A

temporary structure seen in molar tooth development during cap stage and acts as reservoir of cells for the growing enamel organ and may influence crown formation

49
Q

what is enamel cord

A

structure running from the enamel knot to outer enamel epithelium during early bell stage and help determine initial position of 1st cusp during crown pattern formation

50
Q

What happens in the crown stage of tooth development

A

In the crown stage, dentine and enamel begin to form. The inner enamel epithelium cells differentiate into pre-ameloblasts, which induce the formation of odontoblasts from dental papilla. Dentine secretion triggers ameloblast differentiation, initiating enamel formation

DHS2🎐 (8 decks)

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