Development I-Lecture 9/20/21 Flashcards
Embryonic period
First 8 weeks of gestation
Fetal period
The remainder of the gestation period after 8 weeks
Gametes
Specialized germ cells from the male and the female, haploid in chromosome number
End of female gametogenesis
Fertilization
Meiosis
To consecutive cell divisions with one round of DNA replication, leading to haploid cells
Relative size of male and female gametes
Ovum can be 100s of times bigger
Acrosome
Modified Golgi body that contains enzymes necessary to penetrate zona pellucida
Mid-piece of tail
Contains all mitochondria necessary for energy production in the flagella
When are sperm produced
Puberty onward in males
HPO axis
Hypothalamus to pituatary to ovary axis
Hormone production by hypothalamus
GnRH, stimulates pituitary
Hormone production by pituitary
FSH and LH, stimulates the ovaries
Hormone production by the ovaries
Estrogen and progesterone, stimulates the uterus
GnRH mechanism of action
Stimulates the synthesis and secretion of FSH and LH
FSH mechanism of action
Stimulates ovarian follicle growth, differentiation and steroidogenesis
LH mechanism of action
Stimulates ovulation, corpus outrun formation and steroidogenesis
Progestins source
Corpus luteum
LH surge
A sharp increase in LH plasma levels that stimulates ovulation caused by increase in estrogen levels
Primary follicle
Oocyte is arrested in prophase of meiosis I
Secondary follicul
Stimulated by LH surge, arrested in metaphase of meiosis II
Graafian follicle
The mature follicle that gets ovulated
Ovulation
PGE2 stimulates muscle contraction of the thecal cells surrounding follicle, expelling the oocyte towards the Fallopian tube
Zona palucida
Proteinacious zone surrounding oocytes
Cumulus oophorus
Cells that attach the oocytes to the follicular cells
Antrum
Follicular portion that is filled with nutrient rich fluids
Follicular secretion
FSH stimulated 8-12 follicles to grow every month and secrete estrogen
What determines the dominant follicle
Fastest growing follicle, has the most FSH receptors
Degeneration of losing follicles
Degenerate via apoptosis
Theca cells
The smooth muscle like cells that is triggered by PGE2
Corona Radiata
The few layers of follicular cells that go with the egg after ovulation
Down syndrome
Trisomy 21 caused by the non-disjunction
Fertilization
Occurs in the ampulla of the Fallopian tube, cannot occur in the uterus