Desquamation Flashcards
the most common adverse drug reactions effect is a ____.
rash
the most common drug eruption is a ____.
Maculopapular
Both Urticaria and angioedema are type ____ reactons
1
Drug Induced Urticaria presents as pruritic red ____ and transient. Complications may include ____ .
wheals
angiodema
Drug Induced Urticaria is a ____ Dx. For Tx, discontinue drugs and give ____ (benedryl). If severe give ____ and ____
clinical
H1 Antihistamine
IV steriods
Epinhephrine
on physical exam, fixed drug eruptions ____ in the same location due to subsequent exposure to ____. No lasting effects but will present as sharply demarcated dull red or ____ lesions.
re-occur
drugs
brown
The Dx for fixed drug eruptions is ____ and Tx is simple, avoidance of ____.
Clinical
Drug
Maculopapular drug eruptions makes up for ___% of drug eruptions.
90
Maculopapular drug eruptions
on physical exam this will appear as ____ ,Erythematous, macules and papules. _____ and confluent. ±Fever an will be onset ~ ___ week after drug initiation
Blanching
Symmetric
1
Maculopapular drug eruption Dx is _____. Tx includes D/C Drug unless necessary, and _____ for pruritus. if any inflammation give them _____ steroids.
clinical
Antihistamines
topical
(DIHS) Drug induced hypersenstivity reaction
(DIHS) Drug induced hypersenstivity reaction can be caused by _____, Allopurinol, and Sulfonamides
Anticonvulsants
(DIHS) Drug induced hypersenstivity reaction
On physcial exam, DIHS will present as a ______ involvement viral or flu-like prodrome. a ______ rash often on the face, hand or foor edema.
systemic
morbiliform
(DIHS) Dx is ______. Tx is to immiedatelty d/c ______. Administer IV/ ______. Monitor ______ dysfunction with CBC and CMP
drug
glucocorticoids
organ
Drug eruptions are usually caused by ______ side-effects
medications
on physical exam, Drug eruption will present as a ______. Dx is clinixal, and Tx is dependent on the erruption
Note: watch for systemic involement
rash
Erythema Multiforme is usally initated by an infection specifficaly ______
HSV 1 and 2
Erythema Multiforme
On physical exam, it will present with sharply demarcated red or pink “______ “ lesions. with __ zones. Particularly apparent on the ______ surfaces of Hands and extensor surfaces.
Target
3
Dorsal
for E.M Dx is ______. Tx is self-limited and you would give an antiviral for ______. speciffically ______ 400mg twicde per day. for any symptom relief ______ is an option or topical steroids.
Clinical
acyclovir
antihistamine
With SJS/TEN the patient will present 4-28 days after drug intake, “flu-like” symptoms, malaise, headache, ______ borders and nikolsky sign ______.
Raised
Positive
almost always SJS/TEN (95%) will be due to drugs. specifally ______ or NSAIDs in some cases.
Allopurinol
SJS/TEN Tx involves withdrawing the specific ______ causing this. the patient will need extensive ______ . both will require admission at a _____/_____
Drug
supportive-care
ICU/burn unit
Pityriasis Rosea will have two distinictive characterisitc. First the “ _____ patch” and the “______\_________ “ pattern.
Herald
Christmas Tree
Note: Herald patch can also be “large round oroval patch”
Pityriasis Rosea
on physical exam, on lighter skin the lesion will appear ______ or \________ colored, on dark skin it will appear violet or ______\________ .
pink
salmon
red brown
Dx for Pityriasis Rosea is _______. Tx is primarlly supportive through antihistamines and _______ steroids.
clinical
topical
