Dermatology

Question 1

T-cell lymphoproliferative disorder with cutaneous manifestation

Answer 1

Mycosis Fungoides

Question 2

Paraneoplastic syndrome which appears as explosive appearance of seborrheic keratoses

Answer 2

Leser-Trelat Sign

Question 3

Hallmark of mycosis fungoides

Answer 3

Sezary-Lutzner cells

Question 4

Wheal formation associated with rubbing a previously existing lesional skin seen in mastocytosis

Answer 4

Darier sign

Question 5

Wheal formation evoked by rubbing normal skin

Answer 5

Dermatographism

Question 6

Malignant CD4 T-cells with cerebriform nucleus which band together to infiltrate the epidermis

Answer 6

Pautrier microabscesses

Question 7

Nucleotide excision repair disorder associated with increased risk of cutaneous malignancies

Answer 7

Xeroderma Pigmentosum (AR)

Question 8

2p22 mutation associated with DNA mismatch repair causing internal adenocarcinoma and sebaceous tumors

Answer 8

Muir-Torre Syndrome (AD)

Question 9

Nevoid basal cell syndrome associated with medulloblastomas, ovarian tumors, and odontogenic keratocysts

Answer 9

Gorlin Syndrome (AD)

Question 10

Gene mutation most commonly seen in melanomas

Answer 10

p16/INK4a

Question 11

Benign red-pink nodules with fascicular growth associated with spindle or fusiform cells

Answer 11

Spitz nevus

Question 12

Highly dendritic, highly pigmented mimicker of melanomas

Answer 12

Blue nevus

Question 13

Aggregates of epidermal neutrophils in the stratum spinosum seen in psoriasis

Answer 13

Munro microabscesses

Question 14

Pathognomonic sign for psoriasis associated with pinpoint bleeding upon removal of silvery scales

Answer 14

Auspitz sign

Question 15

Generation of new lesions at sites of trauma which predict a genetic component

Answer 15

Koebner phenomenon

Question 16

Areas of hypergranulosis which appear as while lines on lichen planus plaques

Answer 16

Wickham striae

Question 17

Necrotic basal cells sloughed off into the papillary dermis seen in lichen planus

Answer 17

Civatte bodies

Question 18

Caused by autoantibodies against hemidesmosomes

Answer 18

Bullous pemphigoid

Question 19

Low-grade, or slow-growing, skin cancer tumor that looks like a tiny dome or crater and resolves on its own

Answer 19

Keratoacanthoma

Question 20

Skin infection with this organism is associated with draining sinus tracts

Answer 20

Actinomyces israeli

Question 21

A form of Langerhans cell histiocytosis, with cutaneous seborrheic skin eruptions, as well as hepatosplenomegaly and lymphadenopathy

Answer 21

Letterer-Siwe disease

Question 22

Age spots

Answer 22

Senile lentigines