Dermatological Disease Flashcards
Pathogenesis of lichen planus
Autoimmune induced degeneration of basal layer by CD8 and CD4 T cells stimulating apoptosis or keratinocytes.
Clinical signs of oral lichen planus - cutaneous and oral
Cutaneous:
- Pink papules on flexor surface of extremities eg back of hangs
- Wickhams striae
Oral:
- Buccal mucosa, tongue, gingiva
- Asymptomatic unless ulcerative/erosive
- Keratotic, erosive, bullous, desquamative gingivitis
Diagnosis of lichen plnaus:
- Clinical
- Drug/material history
- Histopathology +/- immunofluorescence
Management of symptomatic lichen planus lesions:
Topical corticosteroid
Acute vesiculobullos mucocutaneous diesease with a wide range of clinical presentations. Mostly young adult males. Type III hypersensitivity. Can be severe with diffuse sloughing and ulceration affecting large surfaces of skin and mucosa.
Erythema Multiforme
Specific clinical characteristic of erythema multiforme
Target lesions
Pemphigus Vulgaris is:
a) Intra-epithelial
b) Sub-epithelial
a) Intra-epithelial
Both Pemphigus Vulgaris and MMP are autoimmune conditions
True or false
Yes
Both MMP and Pemphigus Vulgaris can be tested for using what clinical test:
Positive Nikolsky Sign
Which is more common - MMP or PV
MMP twice as common as PV
Two dermatological diseases which are sometimes characterised by desquamative gingivitis
- Lichen Planus
- Mucous Membrane Pemphigoid
Autoimmune condition which is the most common connective tissue disease. Characteristic butterfly rash of the face.
Lupus Erythematous
Oral presentations of Lupus Erythematosis
- Lesions on the palate, buccal mucosa, gingiva, vermillion border. May resemble OLP. Varying degree of pain, ulceration, eythema, hyperkeratosis.
- Xerostomia, candidosis and periodontitis also.
Management of Erythema Multiforme (hypersensitivity reaction)
- Majority no tx as self limiting
- Symptomatic relief eg antihistamines/topical steroids/LA/Anticeptic mouthwash
