Depressive Disorders/Suicide Flashcards
what is depression?
alteration in mood that is expressed by feelings of sadness, despair, pessimism
loss of intent in usual activities
somatic symptoms
changes in appetite and sleep- eating too much or too little; sleeping too much or too little
what are the different types of mood disorders?
persistent depressive disorder
premenstrual dysphoric disorder
substance/medication-induced depressive disorder
depressive disorder due to another medical condition
major depressive disorder
seasonal affective disorder (SAD)
how long does a person with persistent depressive disorder having feelings of low level depression?
most of the day
majority of days- for at least 2 years
what are the symptoms of persistent depressive disorder?
in order to be diagnosed a person needs to have 2 of the following
poor appetite or overeating
insomnia or hypersomnia
low energy or fatigue
low self-esteem
poor conentration or difficulty making decisions
feelings of hopelessness
NOT severe enough for hospitalization
what are the essential features of premenstrual dysphroic disorder (PMDD)?
at least 5 symptoms appear in last week prior to menses, start to improve at menses onset
mood swings
marked irritability or anger or increased conflict
marked depressed mood, feeling of hopelessness or slef-deprecation
marked anxiety, tension, feeling of being keyed up or on edge
decreased interest in usual activities
difficulty concentrating
lethargy, easy fatigue marked lack of energy
marked change in appetite
hypersomnia or insomnia
breast tenderness, aching, bloating, weight gain
what is the major depressive disorder?
symptoms cause significant distress in employment, social or other areas of functioning
not attributed to other medical conditions or substance abuse
what are the diagnostic criteria for major depressive disorder?
5 or more must be present for two weeks with a change from previous functioning
depressed mood most of the days or nearly every day
anhedonia- unable to experience pleasure
weight/appetite loss of gain
insomnia/hyersomnia
psychomotor agitation or retardation
anergia/fatigue
feel worthless, inappropriate guilt
trouble thinking, concentrating, indecisiveness
recurrent thoughts of death, suicide thoughts, and plans
what are the major depressive disorder episode specifiers in the DSM-IV?
single episode or recurrent episode
mild, moderate, or severe
with or without psychotic features
with catatonic features
with postpartum onset
with seasonal pattern
what are biological risk factors for depression?
genetic
biochemical- deficiency of serotonin, norepinephrine, glutamate, GABA, dopamine, and acetylcholine
hormonal
chronic inflammation
what are psychological risk factors for depression?
cognitive theory- views primary disturbance in depression as cognitive rather than affective
depression is product of negative thinking; to improve mood, need to change the way a person thinks
what are three cognitive distortions that serve as the basis for depression?
- negative expectations of the environment
- negative expectations of the self
- negative expectations of the future
what needs to be observed in the assessment for depression?
affect
mood/anhedonia
thought process- indecisive; trouble making decisions
feelings- hopeless/despair/worthless/inappropriate guilt
cognitive changes- trouble learning and concetrating
physical behavior- anergia, pscyhomotor agitation or retardation. vegetative/catatonic signs of depression
what should the patient/family education include?
nature of illness
management of the illness
support service
what are treatments and interventions for depression?
therapeutic communication
group therapy
family therapy
cognitive therapy
pharmacology
ECT= electroconvulsive therapy, where this utilized inthose note repsonding to treatment or in a severe catatonic state
brain stimulation therapy
what are examples of antidepressant medications?
monoamine oxidase inhibitors (MAOIs)
tricyclic
selective serotonin reuptake inhibitors (SSRI)
serotonin-norepinephrine reuptake inhibitors (SNRI)
serotonin antagonist and reuptake inhibitors (SARI)
norepinephrine-dopamine reuptake inhibitors (NDRI)
noradrenergic and specific serotonergic antidepressants (NaSSAs)
serotonin partial agonist reuptake inhibitors (SPARI)
serotoin modulators
what was the first medications specialized to treat depression?
monoamine oxidase inhibitors (MAOIs)
what are examples of MAOIs?
selegiline transdermal (Emsam)
phenelzine (Nardil)
tranylcypromine (Parnate)
isocarboxazid (Marplan)
what are the foods that needed to be avoided when taking MAOIs?
avoid tyramine containing foods, such as:
aged cheeses
raisins, fava beans, flat Italian beans
red wines
smoked or processed meats/caviar
soy sauce/soy products/fermented foods
what are the foods that needed to be limited when taking MAOIs?
limit amount of:
gouda cheese, American cheese, mozzarella cheese
yogurt, sour cream
avocados
bananas or any over ripe fruit
beer, white wine, coffee, colas, teas, hot chocolate
chocolate
meat extracts= monsodium glutamate, meat tenderizers
what happens when tyramine containing foods and MAOIs are combined?
it causes a hypertensive crisis
what are the signs and symptoms of a hypertensive crisis?
headache
N/V
tachycarida
fever
diaphoresis
epistaxis
chest pain
SOB
vision changes
what is the treatment for hypertensive crisis?
gastric lavage/activated charcoal
IV vasodilators- nitroprusside sodium (Nipride)
what are the drug-to-drug interactions with MAOIs?
any other antidepressant (fatal)
sympathomimetics- cold and congestion tx
stimulants- amphetamines, cocaine
antihypertensive- methyldopa, reserpine
meperidine and opioid narctoics- morphine, codeine
antiparkinsonian agents- levodopa
how many days should someone be discontinued or potentially be starting on MAOIs before/after starting a different antidepressant?
14 days
what are examples of tricyclic antidepressants?
amitriptyline
doxepin (Silenor)
clomipramine (Anafranil)
desipramine (Norpramin)
nortriptyline (Pamelor)
imipramine (Tofranil)
what happens if a patient either taking an MAOIs or tricyclic antidepressant, if there is an overdose?
both can cause cardiac arrhythmias, such as V Tach and V Fib
what are examples of SSRIs?
fluoxetine (Prozac)
sertraline (Zoloft)
paroxetine (Paxil)
citalopram (Celexa)
escitalopram (Lexapro)
fluvoxamine (Luvox)
what are the side effects of SSRIs?
most common is sexual dysfunction (except Lexapro)- can add Buspar/Wellbutrin to help
insomnia
fatigue
headache
N/V/D
agitation
dizzy
dry mouth
hyponatremiaw
what is the discontinuation syndrome from SSRIs?
dizzy
insomnia
nervous
irritable
nausea
agitation