Depression Flashcards
T/F? Pt needs instructions on how to respond to worsened mood, critical for adolescents and young adults?
True
Depression diagnosis criteria?
DSM-5 criteria - at least 5 of the ff sx during the same 2 wk period
Depressed mood
Marked diminished interest/pleasure
Significant weight loss or gain
Insomnia or hypersomnia
Psychomotor agitation or retardation
Fatigue of loss of energy
Feelings of worthlessness
Diminished ability to concentrate
Recurrent Suicidial ideation
What condition need to be rule-out prior to starting antidepressant therapy?
Bipolar disorder
List medications that cause or worsen depression
Beta-blockers, particularly propranolol
Clonidine, Corticosteroids, Cyclosporine
Ethanol
Isotretinion, Indomethacin, Interferons
Methadone, Methyldopa, Methylphenidate/ADHD meds/Atomoxetine
OCPs, anabolic steroids (Pt and medication specific)
Procainamide
Reserpine
Statins (pt specific)
Varenicline
List medical conditions that can cause or worsen depression
Stroke
Parkinson dx
Dementia
Thyroid disorders (esp, hypothyroidism)
Low Vit D levels
Metabolic conditions (hypercalcemia), Multiple sclerosis, Malignancy
OAB
Infectious dx
What’s the lag effect ass with antidepressant?
Physical sx (such as low energy) improve within a few weeks
Psychological sx (such as low mood) may take a month or longer
What Grp of antidepressant is pregnancy cat C? Exception?
SSRIs
Paroxetine (Cat. D)
Paroxetine is usually pregnancy cat D, which formulation of paroxetine is preg cat. X?
Brisdelle
What’s the new warning ass with SSRIs?
Bcuz of potential risk of persistent pulmonary hypertension of the newborn (PPHN)
What grp is the second recommended for pregnancy and depression?
Tricyclics
Which natural pdts may be helpful for depression?
St. John’s wort or SAMe (S-adenosyl-L-methionine)
What’s the issue with using St. John’s wort?
Can’t use with other serotonergic agents
Broad-spectrum CYP450 enzyme inducer and has many significant drug interactions
It’s photosensitizer and serotonergic
What’s a medical food pdt used for depression?
L-methylfolate (Deplin)
List SSRIs (Selective Serotonin Reuptake Inhibitors) agents
Fluoxetine (Prozac)
Paroxetine (Paxil)
Fluvoxamine (Luvox)
Sertraline (Zoloft)
Citalopram (Celexa)
Escitalopram (Lexapro - S-enantiomer of citalopram)
What’s the brand name of Fluoxetine (SSRIs)?
Prozac
What’s the brand name of Paroxetine (SSRIs)?
Paxil
What’s the brand name of Sertraline (SSRIs)?
Zoloft
What’s the brand name of Citalopram (SSRIs)?
Celexa
What’s the brand name of Escitalopram (SSRIs)?
Lexapro (S-enantiomer of citalopram)
CI to SSRIs use?
Potentially lethal DI with MAOIs
General SE of SSRIs?
Sexual SE: reduced libido, ejaculation difficulties, anorgasmia
Somnolence
Insomnia
Nausea
Xerostomia
Diaphoresis (dose-related)
Weakness
Tremor
Dizziness
Headache (may help for migraines if taken continuously)
SE specific to Fluoxetine?
Fluoxetine may be activating. Take dose in AM to prevent this
Which SSRIs SE is of more concern in elderly?
SIADH
Hyponatremia
What may cause an increase in bleeding while using SSRIs?
Concurrent use of:
Anticoagulants
Antiplatelet
NSAIDs
Ginkgo
Thrombolytics
Which SSRI has FDA warning of QT prolongation? In what grp? At what dose?
Citalopram
At > 40mg/day
60+ years - > 20mg/day
How do u switch from fluoxetine daily to fluoxetine weekly?
Start 7 days after last daily dose
Weekly fluoxetine is dosed at 90mg/week
What agent is the SSRI and 5-HT1A partial agonist?
Vilazodone (Viibryd)
Is food a consideration when using Vilazodone (Viibryd), a SSRI and 5-HT1A Partial Agonist?
Yes.
Use with food
SEs of Vilazodone (Viibryd), a SSRI and 5-HT1A Partial Agonist?
Reduced libido (but less sexual SEs compared to SSRI and SNRIs)
Diarrhea
Nausea/vomiting
Insomnia
Bleeding risk and Vilazodone (Viibryd)?
Same as SSRIs (increased bleeding risk with concurrent use of anticoagulants, antiplatelets, NSAIDs, gingko, thrombolytics
List agent that’s SSRI, 5-HT3-1D, 5-HT7 receptor antagonist; 5-HT1A Agonist; and Partial 5-HT1B agonist
Vortioxetine (Brintellex)
SEs of Vortioxetine (Brintellex)?
Same as SSRIs and Vilazodone (increased bleeding risk with concurrent use of anticoagulants, antiplatelets, NSAIDs, gingko, thrombolytics
All SSRI req a 2-wk washout period when going to an MAOI or from an MAOI to an SSRI, except?
Fluoxetine.
Req a 5-week washout period (due to long half-life of at least 7days)
Whats the top choice for antidepressant in cardiac pts?
Sertraline
How should sertraline oral concentrate be used?
Must be diluted before use
Don’t use with disulfiram
List Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs ) agents
Venlafaxine (Effexor, Effexor XR)
Duloxetine (Cymbalta)
Desvenlafaxine (Pristiq)
Levomilnacipran (Fetzima)
What’s the brand name of Venlafaxine (SNRIs)?
Effexor
Effexor XR
What’s the brand name of Duloxetine (SNRIs)?
Cymbalta
What’s the brand name of Desvenlafaxine (SNRIs)?
Pristiq