Dementias, MacIntyre Flashcards
top 3 causes of dementia
alzheimers
vascular
lewy body
majority dementia presents when
> 90 y.o
15-20% >85 y.o
dementia reclassified as
neurocognitive disorders
what is essential in Dx dementia
not due to delirium or other mental Dx
major vs mild dementia
major interferes with ADLs (not independent)
what cognitive domains decline in dementia
complex attention executive function learning/memory language perceptual motor social cognition
what cognitive domains decline in dementia
complex attention executive function learning/memory language perceptual motor social cognition
signs of dementia
aphasia agnosia apraxia progressive onset no clouding of consciousness
which dementia can have clouding of consciousness
lewybody
NT in alzheimers
cholinergic neurons loss
dec Ach
avoid what medsin dementia
anticholinergics!!!
medical workup in dementia
VITAL signs Hx and PE cognitive testing labs neuroimaging when indicated
what labs to order for dementia
CBC, CMP, HIV/Syphilis tests, ammonia, thyroid, B12/Folate, UA, EKG, CXR
differential in dementia
delirium
pseudodementia
benign senescent forgetfullness
medical illness
what are reversible dementias
B12 deficiency folate deficiency tumor infection subdural hematoma NPH
autopsy findings alzheimers
atrophy and enlarged ventricles
risk factors for alzheimers
downs APP female sex head trauma Hx lower education level ApoE alleles
what chromosomes may be assoc with alzheimers
1, 14, 21
what alleles assoc with alzheimers
ApoE e4 increase
ApoE e2 protective