Dementia pharm DSA (Kruse)

Question 1

Acetylcholinesterase inhibitors for dementia?

Answer 1

Donepezil
Galantamine
Rivastigmine

Question 2

Describe pharmacokinetics of the Acetylcholinesterase inhibitors used for dementia

Answer 2

Tertiary and uncharged
Well absorbed from all sites and has CNS distribution
More toxic than polar quaternary

These drugs are Donepezil, Galantamine, Rivastigmine

Question 3

MOA of Memantine?

Answer 3

Antagonist of NMDA type of glutamate receptors

Question 4

Where does Memantine bind?

Answer 4

binds to intra-pore Magnesium site, but with longer dwell time, and thus functions as an effective receptor blocker only under conditions of excessive stimulation

Question 5

Most common SE of Memantine?

Answer 5

Dizziness