Dementia (genetics)

Question 1

Alzheimer’s

Answer 1

Gene(s) associatedPSEN1 (presenilin-1), PSEN2 (presenilin-2), APP (amyloid precursor protein), ApoE (apolipoprotein E)

Question 2

Frontotemporal dementia

Answer 2

Gene(s) associatedPGRN (progranulin), MAPT (tau)

Question 3

Huntington’s disease

Answer 3

Gene(s) associatedIT15 (huntingtin)

Question 4

CADSIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)

Answer 4

Gene(s) associatedNotch3 (notch 3)

Question 5

CADASil

Answer 5

CADASIL often starts with migraines, transient ischemic attacks, strokes, or mood disorders between 35 to 55 years of age. The disease progresses to subcortical dementia associated with pseudobulbar palsy and urinary incontinence.