Dementia Flashcards
hallmarks of DWLB
hallucinations
fluctuating levels of consciousness
genes related to AD
presenelin 1,2
APP
tx mild-mod AD
AchE inhibitors
- rivastigmine, donezepil
tx mod-sev AD
NMDA receptor antagonists
- memantine
picks disease
rapidly progressive frontotemporal dementia
early onset
lacunar infarcts
small infarcts affecting areas i.e. thalamus/basal ganglia»_space; dementia despite small due to areas affected
huntingtons hallmarks
[emotional, cognitive and motor disturbance] siccadic eye movements chorea dystonia personality change
huntingtons genetics
CAG repeat on huntington gene chromosome 4
> 35 repeats ):
penetrance - more repeats = ^ likelihood
1st line DWLB
AchE inhibitors
huntingtons treatment
antidepressants (ones safe in o/d) and counselling = most important - suicide prevention
antipsychotics considered for agitation and chorea