deck_2671190 Flashcards
Chronic Inflammation
Inflammation of prolonged duration or slow progress marked histologically by an infiltration of mononuclear cells (lymphocytes, macrophages, plasma cells) often with proliferation of fibroblasts and fibrosis
Chronic Pyelonephritis
Chronic inflammation of the kidney involving the tubules and interstitium which results in scarring
Crohn’s Disease
A recurrent granulomatous and chronic inflammatory disorder that usually affects the terminal ileum or colon but may occur at any level of the GI tract; results in extensive scarring and fistulae
Diverticulitis
Trapping of fecal material within the diverticular pouch leads to bacterial overgrowth which provokes an inflammator response
Diverticulosis
A colonic disease associated with increasing age in whcih small pockets of mucosa protrude through the muscular wall
Giant Cells
Fused macrophages with very large cytoplasm and multiple nuclei; Two types (Langhans horshoe arranged nuclei) (Foreign body clustered or random nuclei)
Granulation Tissue
so called because grossly, under the scab, it has a granular appearance; characterized by ingrowth of new blood vessels and scar tissue
Granuloma
A specific form of chronic inflammatory response to antigens that cannot be eliminated during the acute inflammatory response; characterized histologically by collections of epitheloid macrophages, rim of lymphocytes, giant cells, and caseus necrosis
Healing by primary intention
healing, following surgical closure, or a wound where the edges are naturally brought together so that only a minimum amount of scar formation occurs
Healing by secondary intention
healing, without the intervention of a surgeon, of a large open wound, leading to extensive scarring
Keloid
and exaggerated form of scar that protrudes upward from the skin that is characterized by the presence of dense connective tissue (more prevalent in african americans)
Miliary
Multiple minute deposites that resmeble “millet seeds”
Scar
A collection of collagen that is the end result of repair of an injury
Ulcer
A local tissue defect, or excavation involving the epithelial surface of an organ or tissue (think healing by secondary intention)