deck_2671127 Flashcards

1
Q

Antibody-dependent cell-mediated cytotoxicity

A

one of the type II hypersensitivity reactions; leukocytes become attached to the antibody-coated target cells and cause cell lysis without phagocytosis

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2
Q

Antigen/antibody complex

A

A combination of antigena and antibody; when both are present in about equal amounts these complexes are poorly soluble and often precipitate in tissue.

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3
Q

Autoimmune reaction/disease

A

a phenomenon in which the body develps and immune reaction that is directed against it’s own organs/tissues

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4
Q

Complement

A

A series of proteins activated by aggregated antibody, bacteria, or cell-attached antibody, which form a complex that damages cell membranes leading to lysis (also releases chemotactic proteins C5a and C3a)

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5
Q

Hypersensitivity

A

a relative term, in which an individual shows evidence of response to a stimulus greater than that of the average person

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6
Q

Type 1 Hypersensitivity

A

Caused by interaction between an allergen and IgE antibodies attached to a mast cell leading to release of histamine and other inflammatory factors. Characterized by allergic reactions or by anaphylactic shock

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7
Q

Type II Hypersensitivity

A

Caused by antibody attachment to cells. This may lead to complement activations, “killer cell” response, or inhibition/stimulation of cellular function

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8
Q

Type III Hypersensitivity

A

Antigen and antibody produce insoluble complexes that deposit in tissues and incite an inflammatory response

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9
Q

Type IV Hypersensitivity

A

Caused by interaction between an antigen and T-lymphocytes only; no antibody response present. In some cases, where antigen is not destroyed by response, it results in the formation of granulomas (think caseus necrosis, giant cells, and epitheloid cells)

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