deck_2670929 Flashcards

1
Q

Bradykinin

A

Polypeptide (think membrane receptor)produced by action of Hageman factor and kallikrein; increases vascular permeability; also causes pain (hyperalgia)

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2
Q

C3a

A

A complement cleavage product; increases vascular permability; “anaphyloxin”; stimulates mast cell histamine release

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3
Q

C3b

A

Remains attached to cells, activated the cell attack sequence of complement which leads to cell lysis; MOST IMPORTANT OPSONIN

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4
Q

C5a

A

A complement cleavage product; increases vascular permeability; strong chemoattractant for neutrophils; “anaphylotoxin”

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5
Q

Chemotaxis

A

The migration of a cell in response to a chemical compound

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6
Q

Histamine

A

Preformed inflammatory mediator; stored in mast cell and platelet granuoles; causes increased vascular permeability

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7
Q

Interleukin-1 (IL-1)

A

Produced by monocytes/macrophages; acts locally to stimulate macrophages, stimulate IL-2 production by T-cells, and maturation of B-cells; systemically incudes fever, acute phase reactant proteins, and neutrophil release from bone marrow

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8
Q

Interleukin-2 (IL-2)

A

Produced by activated T-cells in response to antigen; Stimulates IL-2 receptor expression of T-cells (activation); Stimulates production of Interferon

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9
Q

Interferon

A

A family of polypeptides produced by several different cell types; Stimulated by infection or immune response; Increases type II antigen expression (antigen presentation to T cells, antiviral properties, render tumor cells susceptible to attack, inhibit lymphocyte response)

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10
Q

Leukotriene

A

Produced as a breakdown product of cell phospholipids by Lipoxygenase pathway; Not inhibited by aspirin; most potent at increasing vascular permeability; active relatively late and chemotactic for neutrophils

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11
Q

Opsonin

A

A compound that attaches to a foreign cell, such as a bacterium, and makes it more susceptible to a phagocytic cell (Macrophages or neutrophils)

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12
Q

Platelet Activating Factor (PAF)

A

a phospholipid released from inflammatory cells of various types; activated release of enzymes from polymorphonuclear cell (neutrophils); also causes platelet aggregation

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13
Q

Platelet Derived Growth Factor (PDGF)

A

Released during platelet aggregation; promotes activation and migration of monocytes and stimulates fibroblast frowth to promote healing

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14
Q

Prostaglandins

A

Produced as a breakdown product of cell phospholipids by cyclooxygenase pathway (inhibited by aspirin); in inflammation causes pain, increase vascular permeability, and causes vasodilation; not as potent as leukotrienes; contributes to systemic fever

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15
Q

Thromboxane

A

Produced in platelets as a breakdown product of cell phospholipids by cyclooxygenase pathway (inhibited by aspirin); causes platelet aggregation and adhesion vasoconstriction

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16
Q

Transforming Growth Factor (TGF)

A

produced by platelets, macrophages, and lymphocytes; deactivates macrophages, healing of tissue damage, and inhibits proliferation of lymphocytes (think stops damage)

17
Q

Tumor Necrosis Factor (TNF)

A

Produced by monocytes; causes toxic damage to tumor cells, similar effects to IL-1; increases free radical production by neutrophils and activated eosinophils, responsible for many signs and symptoms of septic shock